Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.

dc.contributor.author

Reese, Aspen T

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Cho, Eugenia H

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Klitzman, Bruce

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Nichols, Scott P

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Wisniewski, Natalie A

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Villa, Max M

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Durand, Heather K

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Jiang, Sharon

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Midani, Firas S

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Nimmagadda, Sai N

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O'Connell, Thomas M

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Wright, Justin P

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Deshusses, Marc A

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David, Lawrence A

dc.date.accessioned

2018-07-01T16:46:16Z

dc.date.available

2018-07-01T16:46:16Z

dc.date.issued

2018-06-19

dc.date.updated

2018-07-01T16:46:15Z

dc.description.abstract

How host and microbial factors combine to structure gut microbial communities remains incompletely understood. Redox potential is an important environmental feature affected by both host and microbial actions. We assessed how antibiotics, which can impact host and microbial function, change redox state and how this contributes to post-antibiotic succession. We showed gut redox potential increased within hours of an antibiotic dose in mice. Host and microbial functioning changed under treatment, but shifts in redox potentials could be attributed specifically to bacterial suppression in a host-free ex vivo human gut microbiota model. Redox dynamics were linked to blooms of the bacterial family Enterobacteriaceae. Ecological succession to pre-treatment composition was associated with recovery of gut redox, but also required dispersal from unaffected gut communities. As bacterial competition for electron acceptors can be a key ecological factor structuring gut communities, these results support the potential for manipulating gut microbiota through managing bacterial respiration.

dc.identifier.issn

2050-084X

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2050-084X

dc.identifier.uri

https://hdl.handle.net/10161/17198

dc.language

eng

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eLife Sciences Publications, Ltd

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eLife

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10.7554/elife.35987

dc.subject

antibiotics

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gut microbiota

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human

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infectious disease

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microbiology

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mouse

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redox potential

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succession

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Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut.

dc.type

Journal article

duke.contributor.orcid

Wright, Justin P|0000-0002-9102-5347

duke.contributor.orcid

David, Lawrence A|0000-0002-3570-4767

pubs.organisational-group

School of Medicine

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Duke

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Biomedical Engineering

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Pratt School of Engineering

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Cell Biology

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Basic Science Departments

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Surgery, Plastic, Maxillofacial, and Oral Surgery

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Surgery

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Clinical Science Departments

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Trinity College of Arts & Sciences

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Biology

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Environmental Sciences and Policy

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Nicholas School of the Environment

pubs.publication-status

Published

pubs.volume

7

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