Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume.
| dc.contributor.author | Madden, David J | |
| dc.contributor.author | Parks, Emily L | |
| dc.contributor.author | Tallman, Catherine W | |
| dc.contributor.author | Boylan, Maria A | |
| dc.contributor.author | Hoagey, David A | |
| dc.contributor.author | Cocjin, Sally B | |
| dc.contributor.author | Packard, Lauren E | |
| dc.contributor.author | Johnson, Micah A | |
| dc.contributor.author | Chou, Ying-Hui | |
| dc.contributor.author | Potter, Guy G | |
| dc.contributor.author | Chen, Nan-Kuei | |
| dc.contributor.author | Siciliano, Rachel E | |
| dc.contributor.author | Monge, Zachary A | |
| dc.contributor.author | Honig, Jesse A | |
| dc.contributor.author | Diaz, Michele T | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2018-01-03T16:07:00Z | |
| dc.date.available | 2018-01-03T16:07:00Z | |
| dc.date.issued | 2017-06 | |
| dc.description.abstract | Age-related decline in fluid cognition can be characterized as a disconnection among specific brain structures, leading to a decline in functional efficiency. The potential sources of disconnection, however, are unclear. We investigated imaging measures of cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume as mediators of the relation between age and fluid cognition, in 145 healthy, community-dwelling adults 19-79 years of age. At a general level of analysis, with a single composite measure of fluid cognition and single measures of each of the 3 imaging modalities, age exhibited an independent influence on the cognitive and imaging measures, and the imaging variables did not mediate the age-cognition relation. At a more specific level of analysis, resting-state functional connectivity of sensorimotor networks was a significant mediator of the age-related decline in executive function. These findings suggest that different levels of analysis lead to different models of neurocognitive disconnection, and that resting-state functional connectivity, in particular, may contribute to age-related decline in executive function. | |
| dc.identifier | ||
| dc.identifier | S0197-4580(17)30096-9 | |
| dc.identifier.eissn | 1558-1497 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Neurobiol Aging | |
| dc.relation.isversionof | 10.1016/j.neurobiolaging.2017.01.027 | |
| dc.subject | Cognition | |
| dc.subject | Cortex | |
| dc.subject | Diffusion tensor imaging | |
| dc.subject | Magnetic resonance imaging | |
| dc.subject | Mediation | |
| dc.subject | Adult | |
| dc.subject | Aged | |
| dc.subject | Cognition | |
| dc.subject | Cognitive Aging | |
| dc.subject | Diffusion Tensor Imaging | |
| dc.subject | Executive Function | |
| dc.subject | Female | |
| dc.subject | Humans | |
| dc.subject | Magnetic Resonance Imaging | |
| dc.subject | Male | |
| dc.subject | Middle Aged | |
| dc.subject | Rest | |
| dc.subject | Sensorimotor Cortex | |
| dc.subject | White Matter | |
| dc.title | Sources of disconnection in neurocognitive aging: cerebral white-matter integrity, resting-state functional connectivity, and white-matter hyperintensity volume. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Madden, David J|0000-0003-2815-6552 | |
| pubs.author-url | ||
| pubs.begin-page | 199 | |
| pubs.end-page | 213 | |
| pubs.organisational-group | Center for Cognitive Neuroscience | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Institute for Brain Sciences | |
| pubs.organisational-group | Duke-UNC Center for Brain Imaging and Analysis | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Geriatric Behavioral Health | |
| pubs.organisational-group | Psychology and Neuroscience | |
| pubs.organisational-group | Radiology | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Student | |
| pubs.organisational-group | Temp group - logins allowed | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published | |
| pubs.volume | 54 |
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