Safety and Pharmacokinetics of Exebacase in an Infant with Disseminated Staphylococcus aureus Infection.
| dc.contributor.author | Moorthy, Ganga S | |
| dc.contributor.author | Greenberg, Rachel G | |
| dc.contributor.author | Hornik, Chi D | |
| dc.contributor.author | Cassino, Cara | |
| dc.contributor.author | Ghahramani, Parviz | |
| dc.contributor.author | Kumar, Karan R | |
| dc.contributor.author | Fowler, Vance G | |
| dc.contributor.author | Cohen-Wolkowiez, Michael | |
| dc.date.accessioned | 2022-02-01T19:54:23Z | |
| dc.date.available | 2022-02-01T19:54:23Z | |
| dc.date.issued | 2021-12-11 | |
| dc.date.updated | 2022-02-01T19:54:23Z | |
| dc.description.abstract | Exebacase, an anti-staphylococcal lysin produced from a bacteriophage-encoded gene, is a promising adjunctive therapy for severe methicillin-resistant Staphylococcus aureus infections. We describe the first infant to receive exebacase, dosing, and pharmacokinetics (PK). Exebacase may be safe and efficacious in children; however, further clinical trials are needed to optimize dosing. | |
| dc.identifier | 6459424 | |
| dc.identifier.issn | 1058-4838 | |
| dc.identifier.issn | 1537-6591 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | |
| dc.relation.isversionof | 10.1093/cid/ciab1015 | |
| dc.subject | Methicillin-resistant Staphylococcus aureus | |
| dc.subject | bacteriophage-derived therapy | |
| dc.subject | endocarditis | |
| dc.subject | exebacase | |
| dc.title | Safety and Pharmacokinetics of Exebacase in an Infant with Disseminated Staphylococcus aureus Infection. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Moorthy, Ganga S|0000-0003-3191-1117 | |
| duke.contributor.orcid | Greenberg, Rachel G|0000-0003-4156-8543 | |
| duke.contributor.orcid | Hornik, Chi D|0000-0002-7656-3657 | |
| duke.contributor.orcid | Kumar, Karan R|0000-0001-9196-6350 | |
| duke.contributor.orcid | Fowler, Vance G|0000-0002-8048-0897 | |
| duke.contributor.orcid | Cohen-Wolkowiez, Michael|0000-0002-2458-2266 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Pediatrics | |
| pubs.organisational-group | Medicine, Infectious Diseases | |
| pubs.organisational-group | Pediatrics, Infectious Diseases | |
| pubs.organisational-group | Pediatrics, Neonatology | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.publication-status | Published |
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