T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.

Zheng, B

Han, S

Kelsoe, G

United States

2016-01-08T18:05:48Z

1996-09-01

After immunization, activated splenic T cells proliferate in periarteriolar lymphoid sheaths (PALS) and subsequently migrate to the lymphoid follicle where they enter nascent germinal centers. Analysis of TCR V(D)J gene rearrangements indicates extensive emigration, frequently involving more than a single white pulp region. These migrants constitute a unique set of T helper cells that express antigen-specific alpha beta TCR, CD3, and CD4, but little or no Thy-1, a differentiation antigen present on the great majority of peripheral murine T lymphocytes. The origin of CD4+ Thy-1 follicular T cells appears to be the Thy+ population in the PALS, as both sets commonly share identical V(D)J rearrangements.

http://www.ncbi.nlm.nih.gov/pubmed/9064325

0022-1007

https://hdl.handle.net/10161/11488

eng

Rockefeller University Press

J Exp Med

Animals

Antigens, Thy-1

Down-Regulation

Female

Germinal Center

Mice

Mice, Inbred C57BL

Models, Biological

Molecular Sequence Data

Phenotype

Receptors, Antigen, T-Cell, alpha-beta

T-Lymphocytes, Helper-Inducer

T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/9064325

1083

1091

3

Basic Science Departments

Duke

Duke Cancer Institute

Duke Human Vaccine Institute

Immunology

Institutes and Centers

School of Medicine

Published

184