Separable codes for read-out of mouse primary visual cortex across attentional states

Loading...
Thumbnail Image

Date

2019

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

170
views
58
downloads

Abstract

Attentional modulation of neuronal activity in sensory cortex could alter perception by enhancing the local representation of attended stimuli or its behavioral read-out downstream. We tested these hypotheses using a task in which mice are cued on interleaved trials to attend visual or auditory targets. Neurons in primary visual cortex (V1) that encode task stimuli have larger visually-evoked responses when attention is directed toward vision. To determine whether the attention-dependent changes in V1 reflect changes in representation or read-out, we decoded task stimuli and choices from population activity. Surprisingly, both visual and auditory choices can be decoded from V1, but decoding takes advantage of unique activity patterns across modalities. Furthermore, decoding of choices, but not stimuli, is impaired when attention is directed toward the opposite modality. The specific effect on choice suggests behavioral improvements with attention are largely due to targeted read-out of the most informative V1 neurons.

Department

Description

Provenance

Citation

Citation

Wilson, Ashley Marie (2019). Separable codes for read-out of mouse primary visual cortex across attentional states. Dissertation, Duke University. Retrieved from https://hdl.handle.net/10161/20144.

Collections


Dukes student scholarship is made available to the public using a Creative Commons Attribution / Non-commercial / No derivative (CC-BY-NC-ND) license.