The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

dc.contributor.author

Guan, Xiaoxiang

dc.contributor.author

Zhao, Hui

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Niu, Jiangong

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Tang, Dongfeng

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Ajani, Jaffer A

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Wei, Qingyi

dc.date.accessioned

2019-02-01T15:07:45Z

dc.date.available

2019-02-01T15:07:45Z

dc.date.issued

2009-10-16

dc.date.updated

2019-02-01T15:07:42Z

dc.description.abstract

Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population.The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity.Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer.Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies.

dc.identifier

1471-230X-9-77

dc.identifier.issn

1471-230X

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1471-230X

dc.identifier.uri

https://hdl.handle.net/10161/17971

dc.language

eng

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Springer Science and Business Media LLC

dc.relation.ispartof

BMC gastroenterology

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10.1186/1471-230x-9-77

dc.subject

Humans

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Stomach Neoplasms

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Genetic Predisposition to Disease

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Vascular Endothelial Growth Factor A

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Logistic Models

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Case-Control Studies

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Genotype

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Haplotypes

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Polymorphism, Single Nucleotide

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Alleles

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Adult

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Aged

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Aged, 80 and over

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Middle Aged

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Female

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Male

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Transforming Growth Factor beta1

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Promoter Regions, Genetic

dc.title

The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.

dc.type

Journal article

duke.contributor.orcid

Wei, Qingyi|0000-0002-3845-9445|0000-0003-4115-4439

pubs.begin-page

77

pubs.issue

1

pubs.organisational-group

School of Medicine

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Duke

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Duke Cancer Institute

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Institutes and Centers

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Population Health Sciences

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Basic Science Departments

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Medicine, Medical Oncology

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Medicine

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Clinical Science Departments

pubs.publication-status

Published

pubs.volume

9

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