Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.

Sun, James

Barth, Katrina

Qiao, Shaoyu

Chiang, Chia-Han

Wang, Charles

Rahimpour, Shervin

Trumpis, Michael

Duraivel, Suseendrakumar

Dubey, Agrita

Wingel, Katie E

Rachinskiy, Iakov

Voinas, Alex E

Ferrentino, Breonna

Southwell, Derek G

Haglund, Michael M

Friedman, Allan H

Lad, Shivanand P

Doyle, Werner K

Solzbacher, Florian

Cogan, Gregory

Sinha, Saurabh R

Devore, Sasha

Devinsky, Orrin

Friedman, Daniel

Pesaran, Bijan

Viventi, Jonathan

2022-08-02T03:43:46Z

2022-08-02T03:43:46Z

2022-01

2022-08-02T03:43:42Z

One-third of epilepsy patients suffer from medication-resistant seizures. While surgery to remove epileptogenic tissue helps some patients, 30-70% of patients continue to experience seizures following resection. Surgical outcomes may be improved with more accurate localization of epileptogenic tissue. We have previously developed novel thin-film, subdural electrode arrays with hundreds of microelectrodes over a 100-1000 mm² area to enable high-resolution mapping of neural activity. Here, we used these high-density arrays to study microscale properties of human epileptiform activity. We performed intraoperative micro-electrocorticographic recordings in nine patients with epilepsy. In addition, we recorded from four patients with movement disorders undergoing deep brain stimulator implantation as non-epileptic controls. A board-certified epileptologist identified microseizures, which resembled electrographic seizures normally observed with clinical macroelectrodes. Recordings in epileptic patients had a significantly higher microseizure rate (2.01 events/min) than recordings in non-epileptic subjects (0.01 events/min; permutation test, P = 0.0068). Using spatial averaging to simulate recordings from larger electrode contacts, we found that the number of detected microseizures decreased rapidly with increasing contact diameter and decreasing contact density. In cases in which microseizures were spatially distributed across multiple channels, the approximate onset region was identified. Our results suggest that micro-electrocorticographic electrode arrays with a high density of contacts and large coverage are essential for capturing microseizures in epilepsy patients and may be beneficial for localizing epileptogenic tissue to plan surgery or target brain stimulation.

fcac122

2632-1297

2632-1297

https://hdl.handle.net/10161/25562

eng

Oxford University Press (OUP)

Brain communications

10.1093/braincomms/fcac122

ECoG

epilepsy

intraoperative

microelectrode

microseizure

Intraoperative microseizure detection using a high-density micro-electrocorticography electrode array.

Journal article

Southwell, Derek G|0000-0001-6465-3869

Haglund, Michael M|0000-0002-6332-0808

Lad, Shivanand P|0000-0003-4991-5319

Cogan, Gregory|0000-0003-1557-6507

fcac122

3

Duke

Fuqua School of Business

Pratt School of Engineering

School of Medicine

Basic Science Departments

Clinical Science Departments

Neurobiology

Thomas Lord Department of Mechanical Engineering and Materials Science

Orthopaedics

Pathology

Institutes and Provost's Academic Units

University Institutes and Centers

Duke Global Health Institute

Duke Institute for Brain Sciences

Neurology

Neurology, Neurocritical Care

Neurology, Epilepsy and Sleep

Initiatives

Neurosurgery

Duke Innovation & Entrepreneurship

Duke - Margolis Center for Health Policy

Regeneration Next Initiative

Innovation & Entrepreneurship Initiative

Published

4