KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells.
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The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient sensing, proteostasis and stress resistance in both normal and cancer cells.
Published Version (Please cite this version)
Chen, Po-Han, Jen-Tsan Chi and Michael Boyce (2017). KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells. Molecular & cellular oncology, 4(6). p. e1361501. 10.1080/23723556.2017.1361501 Retrieved from https://hdl.handle.net/10161/19693.
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