KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells.
| dc.contributor.author | Chen, Po-Han | |
| dc.contributor.author | Chi, Jen-Tsan | |
| dc.contributor.author | Boyce, Michael | |
| dc.date.accessioned | 2020-01-01T17:00:21Z | |
| dc.date.available | 2020-01-01T17:00:21Z | |
| dc.date.issued | 2017-01 | |
| dc.date.updated | 2020-01-01T17:00:20Z | |
| dc.description.abstract | The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient sensing, proteostasis and stress resistance in both normal and cancer cells. | |
| dc.identifier | 1361501 | |
| dc.identifier.issn | 2372-3556 | |
| dc.identifier.issn | 2372-3556 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Informa UK Limited | |
| dc.relation.ispartof | Molecular & cellular oncology | |
| dc.relation.isversionof | 10.1080/23723556.2017.1361501 | |
| dc.title | KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Chi, Jen-Tsan|0000-0003-3433-903X | |
| duke.contributor.orcid | Boyce, Michael|0000-0002-2729-4876 | |
| pubs.begin-page | e1361501 | |
| pubs.issue | 6 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Pharmacology & Cancer Biology | |
| pubs.organisational-group | Radiation Oncology | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine, Rheumatology and Immunology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Biochemistry | |
| pubs.publication-status | Published | |
| pubs.volume | 4 |
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