Early hematopoietic effects of chronic radiation exposure in humans.

Abstract

The major goal of this study is to investigate and quantitatively describe the nature of the relationship between the characteristics of chronic exposure to ionizing radiation and specific patterns of hematopoiesis reduction. The study is based on about 3,200 hemograms taken for inhabitants of the Techa riverside villages over the years 1951-1956, i.e., the period characterized by a gradual decrease in dose rates. The mean cumulative red bone marrow dose was 333.6 + or - 4.6 mGy. The approach to statistical analyses involved both empirical methods and modeling (generalized linear models and logistic regressions). The results of the analyses highlighted a gradual increase in the frequency of cytopenias with dose rate. The impact of exposure on hematopoiesis reduction patterns was found to be more substantial than that of age and health status. Dose rates resulting in a two-fold increase in the frequency of cytopenias have been estimated.

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Citation

Published Version (Please cite this version)

10.1097/HP.0b013e3181c2f315

Publication Info

Akleyev, Alexander V, Igor V Akushevich, Georgy P Dimov, Galina A Veremeyeva, Tatyana A Varfolomeyeva, Svetlana V Ukraintseva and Anatoly I Yashin (2010). Early hematopoietic effects of chronic radiation exposure in humans. Health Phys, 99(3). pp. 330–336. 10.1097/HP.0b013e3181c2f315 Retrieved from https://hdl.handle.net/10161/14860.

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Scholars@Duke

Igor Akushevich

Research Professor in the Social Science Research Institute
Ukraintseva

Svetlana Ukraintseva

Research Professor in the Social Science Research Institute

Dr. Ukraintseva studies causes of human aging and related decline in resilience, to identify genetic and other factors responsible for the increase in mortality risk with age eventually limiting longevity. She explores complex relationships, including trade-offs, between physiological aging-changes and risks of major diseases (with emphasis on Alzheimer’s and cancer), as well as survival, to find new genetic and other targets for anti-aging interventions and disease prevention. She also investigates possibilities of repurposing of existing vaccines and treatments for AD prevention and interventions into the aging. For this, Dr. Ukraintseva and her team use data from several large human studies containing rich genetic and phenotypic information (including longitudinal measurements) on thousands of individuals. Dr. Ukraintseva is a PI and Key Investigator on several NIH funded grants, and has more than 130 peer-reviewed publications, including in major journals such as Nature Reviews, Stroke, European Journal of Human Genetics, and some other.

Yashin

Anatoli I. Yashin

Research Professor in the Social Science Research Institute

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