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Access status: Open Access ,
Testing peripheral and central therapies for provoked vestibulodynia: results from the UPDATe trial
(Annals of Medicine, 2026-12-31) Shudt, Chloe; Carey, Erin T; Geller, Elizabeth J; Rapkin, Andrea; Farb, Debbie; Cutting, Haley; Akaninwor, Jasmyn; DeLaRosa, Jesse; Stirling, Christopher; Bortsov, Andrey; Rowe, Pearl; Luo, Sheng; Klein, Marguerita E; Nackley, Andrea G
Access status: Open Access ,
Long-term safety of the Pfizer-BioNTech COVID-19 vaccine: Results from the HERO-together study.
(Respiratory medicine, 2026-06) O'Brien, Emily C; Wong, Cherise; DeLaRosa, Jesse M; Aberle, Laura H; Webb, Laura; Rubino, Heather; Kendrick, Katherine; Mather, Susan; Huynh, Joy; Skinner, Halcyon G; Cohen, Lauren W; Shostak, Jack; Cai, Bing; Caubel, Patrick; Rockhold, Frank W; Stallings, Amy; Lopes, Renato D; Hernandez, Adrian F
<h4>Background</h4>COVID-19 vaccines were initially authorized based on short-term data from Phase 3 clinical trials in a highly selected population.<h4>Objectives</h4>This study assessed the long-term safety of the Pfizer-BioNTech COVID-19 vaccine BNT162b2 and variation in adverse event rates across clinically important subgroups.<h4>Methods</h4>This 24-month prospective safety surveillance study was conducted using a participant-facing portal with centralized event adjudication. Participants included 19,858 adults receiving a COVID-19 vaccine in the US from any manufacturer in the 60 days before enrollment. The main outcome measures were adverse events of special interest (AESIs) and all-cause hospitalizations, with event rate ratios evaluated using the self-controlled risk interval method.<h4>Results</h4>Of the 9518 participants (median age 36.6 years) in the primary safety population (vaccinated with BNT162b2 within 10 days of enrollment), most were female (69.0%), White (66.1%), and non-Hispanic (75.2%). The most frequent baseline health conditions were obesity/overweight (24.4%), hypertension (11.9%), and asthma (11.6%). The overall AESI rate was 13.65 per 1000 person-years. Most AESIs did not result in hospitalization (67.4%). The most common AESIs per 1000 person-years were arthritis/arthralgia (3.32), non-anaphylactic allergic reactions (2.84), and spontaneous abortion/stillbirth (3.10). The rate of all other AESIs was <1.0 per 1000 person-years. Unadjusted AESI rates (IRR; 95% CI) were higher in risk intervals than control intervals (2.32; 1.54-3.51) but were attenuated following adjustment for age (0.95; 0.53-1.72).<h4>Conclusions</h4>AESI risk was low; the most common AESIs were arthritis/arthralgia and non-severe allergic reactions, with no increased incidence of a composite AESI or all-cause hospitalization post-vaccination. BNT162b2 has a favorable long-term safety profile in real-world settings.
Access status: Open Access ,
(Dis)Belief in God Among Younger and Older Poles: Analytic Thinking and Cultural Learning Between Generations and Over Time
(Journal for the Scientific Study of Religion, 2026-01-01) Łowicki, P; Tokarz, J; Laskowski, P; Kiszkiel, Ł; DeLaRosa, JM
Religious disbelief is increasing worldwide, yet its cognitive and cultural foundations remain debated. We examined how analytic thinking and cultural learning shape (dis)belief across generations and over time. Study 1 compared younger (18–39, n = 427) and older (40+, n = 639) Polish adults. Younger adults displayed higher analytic thinking and lower belief in God, and analytic thinking was negatively associated with belief across the full sample. Study 2 replicated this pattern in two nationally representative samples (younger: n = 845; older: n = 880) and showed that younger adults scored lower on exposure to credible childhood religious modeling (CREDs). Although both analytic thinking and CREDs predicted disbelief, their interaction was nonsignificant. Cross-lagged longitudinal analyses over 6 and 12 months indicated that bidirectional effects did not hold after accounting for stable individual differences. These findings suggest that the link between analytic thinking and belief reflects a stable trait-like pattern.
Access status: Open Access ,
Near-infrared photochromic miniprotein enables photoacoustic molecular imaging of acute inflammation and intracellular antigens
(Nature Methods) Oliinyk, Olena S; Xu, Yirui; Luo, Jinhuan; Tokarchuk, Kateryna O; Manoilov, Kyrylo Yu; van de Klashorst, Josie; Eyring, Matthew P; Wang, Mu-en; Chen, Ming; Song, Pengfei; Hickey, John W; Yao, Junjie; Verkhusha, Vladislav V
<jats:title>Abstract</jats:title> <jats:p>Using near-infrared photoswitchable photochromic genetically encoded probes, differential photoacoustic tomography (PAT) enables deep-tissue imaging with high resolution and sensitivity; however, current bacteriophytochrome-based probes are bulky multidomain proteins exceeding 55 kDa, which constrains their use for designing PAT molecular reporters. Here we engineer rsmiRFPnano, a compact cyanobacteriochrome-derived photoswitchable PAT probe. With a molecular weight below 19 kDa, rsmiRFPnano efficiently incorporates biliverdin, exhibits high extinction coefficients in both photochromic states and demonstrates robust performance in live cells. We established rsmiRFPnano-based reporters for NF-κB and AP-1 pathways, which display low basal activity and strong activation-dependent responses. These reporters effectively visualized acute inflammation using noninvasive PAT in vivo, further validated through cellular-level spatial omics mapping. We then created photoswitchable nanobody probes, rsNIR-Fbs, stabilized upon antigen binding and rapidly degraded otherwise, enabling selective photoacoustic immuno-imaging of intracellular antigens in vivo. Together, these results establish rsmiRFPnano as an ultracompact and versatile platform for molecular PAT.</jats:p>
Access status: Open Access ,
Reimagining Redress: Comparing Organizers’ and Survivors’ Perceptions on the Efficacy of the Tokyo Women’s Tribunal
(2026) Holley, Laurel
The Women’s International War Crimes Tribunal on Japan’s Military Sexual Slavery of 2000 (TWT) was a people’s tribunal established to bring justice to survivors of the Japanese Imperial Army’s “comfort women” system, a structure of sexual subjugation organized by the Japanese empire from 1932 through 1945. The organizers of the TWT sought to raise public awareness and compile a substantial body of legal evidence of the atrocity, while survivors predominantly pursued an admission of responsibility from the Japanese state government. At the TWT’s end, organizers walked away satisfied by the amount of public support and evidence that the proceedings had elicited. Survivors’ goal of a state apology remained unmet; however, they expressed their satisfaction at being heard by the general public. This project uncovers this divergence in involved constituencies’ perceptions of TWT efficacy. Though the Tribunal was a relative success by the metric of both organizers and survivors, it did fail to fully cater to survivors’ demands. This shortcoming reveals a deeper problem, in need of resolution: there exist few justice mechanisms that respond directly to the expressed wants of survivors for life after sexual violence.