Browsing by Author "Anthony, JC"

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    Panic attacks and suicide attempts in mid-adolescence.
    (The American journal of psychiatry, 1999-10) Pilowsky, DJ; Wu, LT; Anthony, JC
    OBJECTIVE: The aim of this study was to investigate the association of panic attacks and suicide attempts in a community-based sample of 13-14-year-old adolescents. METHOD: The data are from a survey of 1,580 students in an urban public school system located in the mid-Atlantic region of the United States. Logistic regression methods were used to estimate associations between panic attacks and suicidal ideation and suicide attempts. RESULTS: Controlling for demographic factors, major depression, the use of alcohol, and the use of illicit drugs, the authors found that adolescents with panic attacks were three times more likely to have expressed suicidal ideation and approximately two times more likely to have made suicide attempts than were adolescents without panic attacks. CONCLUSIONS: This new epidemiologic research adds to the evidence of an association between panic attacks and suicide attempts during the middle years of adolescence.
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    The estimated rate of depressed mood in US adults: recent evidence for a peak in later life.
    (Journal of affective disorders, 2000-11) Wu, LT; Anthony, JC
    OBJECTIVE:The main aim of this study is to add new evidence on the descriptive epidemiology of depressed mood, and to investigate suspected determinants for depressed mood in adulthood. METHODS:The data are from a continuing survey of a nationally representative sample of adult household residents in the United States, conducted in 1995 and 1996, totaling 26,883 respondents. Multiple logistic regression procedures yielded estimated associations. RESULTS:We found that an estimated 1.9% of adult females and 1.0% of adult males experience a spell of sustained depressed mood during a span of approximately 2 weeks duration (i.e. point prevalence). For most of these cases, this is not the first spell. Among women, the smoothed curve for the prevalence estimates shows a peak in the youngest age stratum and decreases across age strata before 60 years, and has a slight secondary peak thereafter. In contrast, for males, the prevalence estimates of depression show no peak in the older age strata. Evidence from logistic regression analyses supports the inference of this later life peak in frequency of depressed mood among women. These new findings add to a growing body of epidemiological evidence on age and depression, and provoke new questions about the possibly etiological relationships involving social structural characteristics of local neighborhoods in combination with individual-level risk factors that have received primary attention in recent psychiatric epidemiology. CONCLUSIONS:These findings point to the need for further etiological research, including studies of relationships between social structural characteristics of local neighborhoods and the occurrence of spells of depressed mood, as well as clinical implications for depression mood in late life.
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    The use of the case-crossover design in studying illicit drug use.
    (Substance use & misuse, 2000-05) Wu, LT; Anthony, JC
    The case-crossover design was developed to study time-varying exposures that cause transient excess risk of acute health events. It is a variant of case-control and subject-as-own-control research designs, involving use of information about exposure history of each case to estimate the transient effect. This kind of self-control design can help to reduce sampling bias otherwise introduced in the selection of controls, as well as confounding bias that might be derived from enduring individual characteristics, especially personality traits and other long-standing inherited or acquired vulnerabilities. When the subject is used as his or her own control, these personal vulnerabilities are matched. In this paper we discuss strengths and weaknesses of the case-crossover design and suggest applications of the case-crossover design in epidemiologic studies on suspected hazards of illicit drug use, and in studies of drug use and co-occurring psychiatric disturbances. We conclude that the case-crossover design can play a useful role, but it discloses a need to secure fine-grained measurements in epidemiologic research on psychiatric comorbidity. As explained in the paper, we also believe the case-crossover method may be of use to criminologists who study the drugs-crime nexus, to services researchers and clinicians who seek to understand treatment entry and compliance behavior, and to etiologists interested in polydrug use.
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    Tobacco smoking and depressed mood in late childhood and early adolescence.
    (American journal of public health, 1999-12) Wu, LT; Anthony, JC
    OBJECTIVES:This study builds on previous observations about a suspected causal association linking tobacco smoking with depression. With prospective data, the study sheds new light on the temporal sequencing of tobacco smoking and depressed mood in late childhood and early adolescence. METHODS:The epidemiologic sample that was studied consisted of 1731 youths (aged 8-9 to 13-14 years) attending public schools in a mid-Atlantic metropolitan area, who were assessed at least twice from 1989 to 1994. A survival analysis was used to examine the temporal relationship from antecedent tobacco smoking to subsequent onset of depressed mood, as well as from antecedent depressed mood to subsequent initiation of tobacco use. RESULTS:Tobacco smoking signaled a modestly increased risk for the subsequent onset of depressed mood, but antecedent depressed mood was not associated with a later risk of starting to smoke tobacco cigarettes. CONCLUSIONS:This evidence is consistent with a possible causal link from tobacco smoking to later depressed mood in late childhood and early adolescence, but not vice versa.
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    Tobacco smoking and other suspected antecedents of nonmedical psychostimulant use in the United States, 1995.
    (Substance use & misuse, 1999-07) Wu, LT; Anthony, JC
    This study investigates the extent to which tobacco smoking is associated with the nonmedical use of psychostimulants and the temporal order of the age of first use for tobacco and psychostimulants within a nationally representative sample of United States household residents. At the same time, alcohol use and other suspected determinants of psychostimulant use are investigated and held constant, using multiple regression models. Data were taken from public use files of the 1995 National Household Survey on Drug Abuse. Conditional logistic regression analyses were performed to derive estimated relative odds of using stimulants for tobacco smokers versus nonsmokers, holding constant other potentially distorting influences. This study provides recent evidence on tobacco smoking as one of the potentially malleable risk factors for the nonmedical use of stimulant drugs.