Browsing by Author "Kolamunnage-Dona, Ruwanthi"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Open Access Erratum to: Methods for evaluating medical tests and biomarkers.(Diagnostic and prognostic research, 2017-01) Gopalakrishna, Gowri; Langendam, Miranda; Scholten, Rob; Bossuyt, Patrick; Leeflang, Mariska; Noel-Storr, Anna; Thomas, James; Marshall, Iain; Wallace, Byron; Whiting, Penny; Davenport, Clare; Leeflang, Mariska; GopalaKrishna, Gowri; de Salis, Isabel; Mallett, Sue; Wolff, Robert; Whiting, Penny; Riley, Richard; Westwood, Marie; Kleinen, Jos; Collins, Gary; Reitsma, Hans; Moons, Karel; Zapf, Antonia; Hoyer, Annika; Kramer, Katharina; Kuss, Oliver; Ensor, J; Deeks, JJ; Martin, EC; Riley, RD; Rücker, Gerta; Steinhauser, Susanne; Schumacher, Martin; Riley, Richard; Ensor, Joie; Snell, Kym; Willis, Brian; Debray, Thomas; Moons, Karel; Deeks, Jon; Collins, Gary; di Ruffano, Lavinia Ferrante; Willis, Brian; Davenport, Clare; Mallett, Sue; Taylor-Phillips, Sian; Hyde, Chris; Deeks, Jon; Mallett, Sue; Taylor, Stuart A; Batnagar, Gauraang; STREAMLINE COLON Investigators; STREAMLINE LUNG Investigators; METRIC Investigators; Taylor-Phillips, Sian; Di Ruffano, Lavinia Ferrante; Seedat, Farah; Clarke, Aileen; Deeks, Jon; Byron, Sarah; Nixon, Frances; Albrow, Rebecca; Walker, Thomas; Deakin, Carla; Hyde, Chris; Zhelev, Zhivko; Hunt, Harriet; di Ruffano, Lavinia Ferrante; Yang, Yaling; Abel, Lucy; Buchanan, James; Fanshawe, Thomas; Shinkins, Bethany; Wynants, Laure; Verbakel, Jan; Van Huffel, Sabine; Timmerman, Dirk; Van Calster, Ben; Leeflang, Mariska; Zwinderman, Aeliko; Bossuyt, Patrick; Oke, Jason; O'Sullivan, Jack; Perera, Rafael; Nicholson, Brian; Bromley, Hannah L; Roberts, Tracy E; Francis, Adele; Petrie, Denniis; Mann, G Bruce; Malottki, Kinga; Smith, Holly; Deeks, Jon; Billingham, Lucinda; Sitch, Alice; Mallett, Sue; Deeks, Jon; Gerke, Oke; Holm-Vilstrup, Mie; Segtnan, Eivind Antonsen; Halekoh, Ulrich; Høilund-Carlsen, Poul Flemming; Francq, Bernard G; Deeks, Jon; Sitch, Alice; Dinnes, Jac; Parkes, Julie; Gregory, Walter; Hewison, Jenny; Altman, Doug; Rosenberg, William; Selby, Peter; Asselineau, Julien; Perez, Paul; Paye, Aïssatou; Bessede, Emilie; Proust-Lima, Cécile; Naaktgeboren, Christiana; de Groot, Joris; Rutjes, Anne; Bossuyt, Patrick; Reitsma, Johannes; Moons, Karel; Collins, Gary; Ogundimu, Emmanuel; Cook, Jonathan; Le Manach, Yannick; Altman, Doug; Wynants, Laure; Vergouwe, Yvonne; Van Huffel, Sabine; Timmerman, Dirk; Van Calster, Ben; Pajouheshnia, Romin; Groenwold, Rolf; Moons, Karen; Reitsma, Johannes; Peelen, Linda; Van Calster, Ben; Nieboer, Daan; Vergouwe, Yvonne; De Cock, Bavo; Pencina, Micael J; Steyerberg, Ewout W; Cooper, Jennifer; Taylor-Phillips, Sian; Parsons, Nick; Stinton, Chris; Smith, Steve; Dickens, Andy; Jordan, Rachel; Enocson, Alexandra; Fitzmaurice, David; Sitch, Alice; Adab, Peymane; Francq, Bernard G; Boachie, Charles; Vidmar, Gaj; Freeman, Karoline; Connock, Martin; Taylor-Phillips, Sian; Court, Rachel; Clarke, Aileen; de Groot, Joris; Naaktgeboren, Christiana; Reitsma, Hans; Moons, Carl; Harris, Jessica; Mumford, Andrew; Plummer, Zoe; Lee, Kurtis; Reeves, Barnaby; Rogers, Chris; Verheyden, Veerle; Angelini, Gianni D; Murphy, Gavin J; Huddy, Jeremy; Ni, Melody; Good, Katherine; Cooke, Graham; Bossuyt, Patrick; Hanna, George; Ma, Jie; Altman, Doug; Collins, Gary; Moons, KGM Carl; de Groot, Joris AH; Mallett, Sue; Altman, Doug G; Reitsma, Johannes B; Collins, Gary S; Moons, Karel GM; Altman, Douglas G; Reitsma, Johannes B; Collins, Gary S; Kamarudin, Adina Najwa; Kolamunnage-Dona, Ruwanthi; Cox, Trevor; Ni, Melody; Huddy, Jeremy; Borsci, Simone; Hanna, George; Pérez, Teresa; Pardo, M Carmen; Candela-Toha, Angel; Muriel, Alfonso; Zamora, Javier; Sanghera, Sabina; Mohiuddin, Syed; Martin, Richard; Donovan, Jenny; Coast, Joanna; Seo, Mikyung Kelly; Cairns, John; Mitchell, Elizabeth; Smith, Alison; Wright, Judy; Hall, Peter; Messenger, Michael; Calder, Nicola; Wickramasekera, Nyantara; Vinall-Collier, Karen; Lewington, Andrew; Pajouheshnia, Romin; Damen, Johanna; Groenwold, Rolf; Moons, Karel; Peelen, Linda; Messenger, Michael; Cairns, David; Smith, Alison; Hutchinson, Michelle; Wright, Judy; Hall, Peter; Calder, Nicola; Sturgeon, Cathie; Mitchel, Liz; Kift, Rebecca; Christakoudi, Sofia; Rungall, Manohursingh; Mobillo, Paula; Montero, Rosa; Tsui, Tjir-Li; Kon, Sui Phin; Tucker, Beatriz; Sacks, Steven; Farmer, Chris; Strom, Terry; Chowdhury, Paramit; Rebollo-Mesa, Irene; Hernandez-Fuentes, Maria; Damen, Johanna AAG; Debray, Thomas PA; Heus, Pauline; Hooft, Lotty; Moons, Karel GM; Pajouheshnia, Romin; Reitsma, Johannes B; Scholten, Rob JPM; Damen, Johanna AAG; Hooft, Lotty; Schuit, Ewoud; Debray, Thomas PA; Collins, Gary S; Tzoulaki, Ioanna; Lassale, Camille M; Siontis, George CM; Chiocchia, Virginia; Roberts, Corran; Schlüssel, Michael Maia; Gerry, Stephen; Black, James A; Heus, Pauline; van der Schouw, Yvonne T; Peelen, Linda M; Moons, Karel GM; Damen, Johanna AAG; Debray, Thomas PA; Heus, Pauline; Hooft, Lotty; Moons, Karel GM; Pajouheshnia, Romin; Reitsma, Johannes B; Scholten, Rob JPM; Ma, Jie; Altman, Doug; Collins, Gary; Spence, Graeme; McCartney, David; van den Bruel, Ann; Lasserson, Daniel; Hayward, Gail; Vach, Werner; de Jong, Antoinette; Burggraaff, Coreline; Hoekstra, Otto; Zijlstra, Josée; de Vet, Henrica; Hunt, Harriet; Hyde, Chris; Graziadio, Sara; Allen, Joy; Johnston, Louise; O'Leary, Rachel; Power, Michael; Allen, Joy; Graziadio, Sara; Johnson, Louise; O'Leary, Rachel; Power, Michael; Waters, Ray; Simpson, John; Johnston, Louise; Allen, Joy; Graziadio, Sara; O'Leary, Rachel; Waters, Ray; Power, Michael; Mallett, Sue; Fanshawe, Thomas R; Phillips, Peter; Plumb, Andrew; Helbren, Emma; Halligan, Steve; Taylor, Stuart A; Gale, Alastair; Mallett, Sue; Sekula, Peggy; Altman, Douglas G; Sauerbrei, Willi; Mallett, Sue; Fanshawe, Thomas R; Forman, Julia R; Dutton, Susan J; Takwoingi, Yemisi; Hensor, Elizabeth M; Nichols, Thomas E; Shinkins, Bethany; Yang, Yaling; Abel, Lucy; Di Ruffano, Lavinia Ferrante; Fanshawe, Thomas; Kempf, Emmanuelle; Porcher, Raphael; de Beyer, Jennifer; Moons, Karel; Altman, Douglas; Reitsma, Hans; Hopewell, Sally; Sauerbrei, Willi; Collins, Gary; Dennis, John; Shields, Beverley; Jones, Angus; Henley, William; Pearson, Ewan; Hattersley, Andrew; MASTERMIND consortium; Heus, Pauline; Damen, Johanna AAG; Pajouheshnia, Romin; Scholten, Rob JPM; Reitsma, Johannes B; Collins, Gary S; Altman, Douglas G; Moons, Karel GM; Hooft, Lotty; Shields, Beverley; Dennis, John; Jones, Angus; Henley, William; Pearson, Ewan; Hattersley, Andrew; MASTERMIND consortium; Scheibler, Fueloep; Rummer, Anne; Sturtz, Sibylle; Großelfinger, Robert; Banister, Katie; Ramsay, Craig; Azuara-Blanco, Augusto; Cook, Jonathan; Boachie, Charles; Burr, Jennifer; Kumarasamy, Manjula; Bourne, Rupert; Uchegbu, Ijeoma; Borsci, Simone; Murphy, Jennifer; Hanna, George; Uchegbu, Ijeoma; Carter, Alex; Murphy, Jen; Ni, Melody; Marti, Joachim; Eatock, Julie; Uchegbu, Ijeoma; Robotham, Julie; Dudareva, Maria; Gilchrist, Mark; Holmes, Alison; Uchegbu, Ijeoma; Borsci, Simone; Monaghan, Phillip; Lord, Sarah; StJohn, Andrew; Sandberg, Sverre; Cobbaert, Christa; Lennartz, Lieselotte; Verhagen-Kamerbeek, Wilma; Ebert, Christoph; Bossuyt, Patrick; Horvath, Andrea; Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine; Jenniskens, Kevin; Naaktgeboren, Christiana; Reitsma, Johannes; Moons, Karel; de Groot, Joris; Hyde, Chris; Peters, Jaime; Grigore, Bogdan; Peters, Jaime; Hyde, Chris; Hyde, Chris; Ukoumunne, Obi; Peters, Jaime; Zhelev, Zhivko; Levis, Brooke; Benedetti, Andrea; Levis, Alexander W; Ioannidis, John PA; Shrier, Ian; Cuijpers, Pim; Gilbody, Simon; Kloda, Lorie A; McMillan, Dean; Patten, Scott B; Steele, Russell J; Ziegelstein, Roy C; Bombardier, Charles H; Osório, Flavia de Lima; Fann, Jesse R; Gjerdingen, Dwenda; Lamers, Femke; Lotrakul, Manote; Loureiro, Sonia R; Löwe, Bernd; Shaaban, Juwita; Stafford, Lesley; van Weert, Henk CPM; Whooley, Mary A; Williams, Linda S; Wittkampf, Karin A; Yeung, Albert S; Thombs, Brett D; Peters, Jaime; Cooper, Chris; Buchanan, James; Nieto, Tom; Smith, Claire; Tucker, Olga; Dretzke, Janine; Beggs, Andrew; Rai, Nirmala; Davenport, Clare; Bayliss, Sue; Stevens, Simon; Snell, Kym; Mallet, Sue; Deeks, Jon; Sundar, Sudha; Hall, Emma; Porta, Nuria; Estelles, David Lorente; de Bono, Johann; CTC-STOP protocol development group[This corrects the article DOI: 10.1186/s41512-016-0001-y.].Item Open Access Population Pharmacodynamics of Amphotericin B Deoxycholate for Disseminated Infection Caused by Talaromyces marneffei.(Antimicrobial Agents and Chemotherapy, 2019-02) Le, Thuy; Ly, Vo Trieu; Thu, Nguyen Thi Mai; Nguyen, Ashley; Thanh, Nguyen Tat; Chau, Nguyen Van Vinh; Thwaites, Guy; Perfect, John; Kolamunnage-Dona, Ruwanthi; Hope, WilliamAmphotericin B deoxycholate (DAmB) is a first-line agent for the initial treatment of talaromycosis. However, little is known about the population pharmacokinetics and pharmacodynamics of DAmB for talaromycosis. Pharmacokinetic data were obtained from 78 patients; among them, 55 patients had serial fungal CFU counts in blood also available for analysis. A population pharmacokinetic-pharmacodynamic model was fitted to the data. The relationships between the area under the concentration-time curve (AUC)/MIC and the time to blood culture sterilization and the time to death were investigated. There was only modest pharmacokinetic variability in the average AUC, with a mean ± standard deviation of 11.51 ± 3.39 mg·h/liter. The maximal rate of drug-induced kill was 0.133 log10 CFU/ml/h, and the plasma concentration of the DAmB that induced the half-maximal rate of kill was 0.02 mg/liter. Fifty percent of patients sterilized their bloodstreams by 83.16 h (range, 13 to 264 h). A higher initial fungal burden was associated with a longer time to sterilization (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.36 to 0.70; P < 0.001). There was a weak relationship between AUC/MIC and the time to sterilization, although this did not reach statistical significance (HR, 1.03; 95% CI, 1.00 to 1.06, P = 0.091). Furthermore, there was no relationship between the AUC/MIC and time to death (HR, 0.97; 95% CI, 0.88 to 1.08; P = 0.607) or early fungicidal activity {slope = log[(0.500 - 0.003·(AUC/MIC)]; P = 0.319} adjusted for the initial fungal burden. The population pharmacokinetics of DAmB are surprisingly consistent. The time to sterilization of the bloodstream may be a useful pharmacodynamic endpoint for future studies. (This study has been registered at the ISRCTN registry under no. ISRCTN59144167.).