Browsing by Author "Li, Lin"
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Item Open Access Impact of Disaster Research on the Development of Early Career Researchers: Lessons Learned from the Wastewater Monitoring Pandemic Response Efforts.(Environmental science & technology, 2022-04) Delgado Vela, Jeseth; McClary-Gutierrez, Jill S; Al-Faliti, Mitham; Allan, Vajra; Arts, Peter; Barbero, Roberto; Bell, Cristalyne; D'Souza, Nishita; Bakker, Kevin; Kaya, Devrim; Gonzalez, Raul; Harrison, Katherine; Kannoly, Sherin; Keenum, Ishi; Li, Lin; Pecson, Brian; Philo, Sarah E; Schneider, Rebecca; Schussman, Melissa K; Shrestha, Abhilasha; Stadler, Lauren B; Wigginton, Krista R; Boehm, Alexandria; Halden, Rolf U; Bibby, KyleItem Open Access Sedimentation analysis on steep slope areas development: Western North Carolina(2008-08-29T16:46:27Z) Li, LinThis project focuses on the rapid development and its concomitant environmental consequences that threaten water resources and the quality of life in Western North Carolina (WNC). The growing popularity of WNC, coupled with the region's topography means that builders are increasingly developing on steep slopes. The influence of steep slope development on sedimentation pollution and corollary hazards is investigated. In particular, the focus is on land development and its potential link to the probability of landslides. . A detail analysis was conducted for potential factors that induce landslides, particularly concentrating on Macon County and Watauga County. Most of the analysis applies Geographic Information System (GIS) technology, therefore gathering data, analyzing them, making them compatible to ArcGIS and developing intuitive map making for ease of visualization. How to expand the conclusions from this project to other steep slope areas are briefly described. Slope is analyzed by different percent degree categories, with a lens on the current legislation of 40 percent degree as the initial point of steep slope definition.Item Open Access Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma.(Scientific reports, 2015-10-27) Li, Chenguang; Gao, Zhibo; Li, Fei; Li, Xiangchun; Sun, Yihua; Wang, Mengyun; Li, Dan; Wang, Rui; Li, Fuming; Fang, Rong; Pan, Yunjian; Luo, Xiaoyang; He, Jing; Zheng, Liangtao; Xia, Jufeng; Qiu, Lixin; He, Jun; Ye, Ting; Zhang, Ruoxin; He, Minghui; Zhu, Meiling; Hu, Haichuan; Shi, Tingyan; Zhou, Xiaoyan; Sun, Menghong; Tian, Shilin; Zhou, Yong; Wang, Qiaoxiu; Chen, Longyun; Yin, Guangliang; Lu, Jingya; Wu, Renhua; Guo, Guangwu; Li, Yingrui; Hu, Xueda; Li, Lin; Asan; Wang, Qin; Yin, Ye; Feng, Qiang; Wang, Bin; Wang, Hang; Wang, Mingbang; Yang, Xiaonan; Zhang, Xiuqing; Yang, Huanming; Jin, Li; Wang, Cun-Yu; Ji, Hongbin; Chen, Haiquan; Wang, Jun; Wei, QingyiLung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in Chinese patients is currently limited. We performed whole exome sequencing in samples from 100 patients with lung SQCCs to search for somatic mutations and the subsequent target capture sequencing in another 98 samples for validation. We identified 20 significantly mutated genes, including TP53, CDH10, NFE2L2 and PTEN. Pathways with frequently mutated genes included those of cell-cell adhesion/Wnt/Hippo in 76%, oxidative stress response in 21%, and phosphatidylinositol-3-OH kinase in 36% of the tested tumor samples. Mutations of Chromatin regulatory factor genes were identified at a lower frequency. In functional assays, we observed that knockdown of CDH10 promoted cell proliferation, soft-agar colony formation, cell migration and cell invasion, and overexpression of CDH10 inhibited cell proliferation. This mutational landscape of lung SQCC in Chinese patients improves our current understanding of lung carcinogenesis, early diagnosis and personalized therapy.