Browsing by Author "Wei, W"
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Item Open Access Dynamical and thermodynamical coupling between the North Atlantic subtropical high and the marine boundary layer clouds in boreal summer(Climate Dynamics, 2017-06-10) Wei, W; Li, W; Deng, Y; Yang, S; Jiang, JH; Huang, L; Liu, WTItem Open Access Evaluation of intracoronary hemodynamics identifies perturbations in vorticity(Frontiers in Systems Biology, 2022-01-01) Vardhan, M; Gounley, J; Chen, SJ; Nair, P; Wei, W; Hegele, L; Kusner, J; Kahn, AM; Frakes, D; Leopold, JA; Randles, ABackground and objective: Coronary artery disease (CAD) is highly prevalent and associated with adverse events. Challenges have emerged in the treatment of intermediate coronary artery stenoses. These lesions are often interrogated with fractional flow reserve (FFR) testing to determine if a stenosis is likely to be causative for ischemia in a cardiac territory. This invasive test requires insertion of a pressure wire into a coronary vessel. Recently computational fluid dynamics (CFD) has been used to noninvasively assess fractional flow reserve in vessels reconstructed from medical imaging data. However, many of these simulations are unable to provide additional information about intravascular hemodynamics, including velocity, endothelial shear stress (ESS), and vorticity. We hypothesized that vorticity, which has demonstrated utility in the assessment of ventricular and aortic diseases, would also be an important hemodynamic factor in CAD. Methods: Three-dimensional (3D), patient-specific coronary artery geometries that included all vessels >1 mm in diameter were created from angiography data obtained from 10 patients who underwent diagnostic angiography and FFR testing (n = 9). A massively parallel CFD solver (HARVEY) was used to calculate coronary hemodynamic parameters including pressure, velocity, ESS, and vorticity. These simulations were validated by comparing velocity flow fields from simulation to both velocities derived from in vitro particle image velocimetry and to invasively acquired pressure wire-based data from clinical testing. Results: There was strong agreement between findings from CFD simulations and particle image velocimetry experimental testing (p < 0.01). CFD-FFR was also highly correlated with invasively measured FFR (ρ = 0.77, p = 0.01) with an average error of 5.9 ± 0.1%. CFD-FFR also had a strong inverse correlation with the vorticity (ρ = -0.86, p = 0.001). Simulations to determine the effect of the coronary stenosis on intravascular hemodynamics demonstrated significant differences in velocity and vorticity (both p < 0.05). Further evaluation of an angiographically normal appearing non-FFR coronary vessel in patients with CAD also demonstrated differences in vorticity when compared with FFR vessels (p < 0.05). Conclusion: The use of highly accurate 3D CFD-derived intravascular hemodynamics provides additional information beyond pressure measurements that can be used to calculate FFR. Vorticity is one parameter that is modified by a coronary stenosis and appears to be abnormal in angiographically normal vessels in patients with CAD, highlighting a possible use-case in preventative screening for early coronary disease.Item Open Access LEGEND-1000 Preconceptual Design ReportCollaboration, LEGEND; Abgrall, N; Abt, I; Agostini, M; Alexander, A; Andreoiu, C; Araujo, GR; III, FT Avignone; Bae, W; Bakalyarov, A; Balata, M; Bantel, M; Barabanov, I; Barabash, AS; Barbeau, PS; Barton, CJ; Barton, PJ; Baudis, L; Bauer, C; Bernieri, E; Bezrukov, L; Bhimani, KH; Biancacci, V; Blalock, E; Bolozdynya, A; Borden, S; Bos, B; Bossio, E; Boston, A; Bothe, V; Bouabid, R; Boyd, S; Brugnera, R; Burlac, N; Busch, M; Caldwell, A; Caldwell, TS; Carney, R; Cattadori, C; Chan, Y-D; Chernogorov, A; Christofferson, CD; Chu, P-H; Clark, M; Cohen, T; Combs, D; Comellato, T; Cooper, RJ; Costa, IA; D'Andrea, V; Detwiler, JA; Giacinto, A Di; Marco, N Di; Dobson, J; Drobizhev, A; Durand, MR; Edzards, F; Efremenko, Yu; Elliott, SR; Engelhardt, A; Fajt, L; Faud, N; Febbraro, MT; Ferella, F; Fields, DE; Fischer, F; Fomina, M; Fox, H; Franchi, J; Gala, R; Galindo-Uribarri, A; Gangapshev, A; Garfagnini, A; Geraci, A; Gilbert, C; Gold, M; Gooch, C; Gradwohl, KP; Green, MP; Grinyer, GF; Grobov, A; Gruszko, J; Guinn, I; Guiseppe, VE; Gurentsov, V; Gurov, Y; Gusev, K; Hacket, B; Hagemann, F; Hakenmüeller, J; Haranczyk, M; Hauertmann, L; Haufe, CR; Hayward, C; Heffron, B; Henkes, F; Henning, R; Aguilar, D Hervas; Hinton, J; Hodak, R; Hoffmann, H; Hofmann, W; Hostiuc, A; Huang, J; Hult, M; Mirza, M Ibrahim; Jochum, J; Jones, R; Judson, D; Junker, M; Kaizer, J; Kazalov, V; Kermaïdic, Y; Khushbakht, H; Kidd, M; Kihm, T; Kilgus, K; Kim, I; Klimenko, A; Knöpfle, KT; Kochetov, O; Konovalov, SI; Kontul, I; Kool, K; Kormos, LL; Kornoukhov, VN; Korosec, M; Krause, P; Kuzminov, VV; López-Castaño, JM; Lang, K; Laubenstein, M; León, E; Lehnert, B; Leonhardt, A; Li, A; Lindner, M; Lippi, I; Liu, X; Liu, J; Loomba, D; Lubashevskiy, A; Lubsandorzhiev, B; Lusardi, N; Müller, Y; Macko, M; Macolino, C; Majorovits, B; Mamedov, F; Maneschg, W; Manzanillas, L; Marshall, G; Martin, RD; Martin, EL; Massarczyk, R; Mei, D; Meijer, SJ; Mertens, S; Misiaszek, M; Mondragon, E; Morella, M; Morgan, B; Mroz, T; Muenstermann, D; Nave, CJ; Nemchenok, I; Neuberger, M; Oli, TK; Gann, G Orebi; Othman, G; Palušova, V; Panth, R; Papp, L; Paudel, LS; Pelczar, K; Perez, J Perez; Pertoldi, L; Pettus, W; Piseri, P; Poon, AWP; Povinec, P; Pullia, A; Radford, DC; Ramachers, YA; Ransom, C; Rauscher, L; Redchuk, M; Reine, AL; Riboldi, S; Rielage, K; Rozov, S; Rukhadze, E; Rumyantseva, N; Runge, J; Ruof, NW; Saakyan, R; Sailer, S; Salamanna, G; Salamida, F; Salvat, DJ; Sandukovsky, V; Schönert, S; Schültz, A; Schütt, M; Schaper, DC; Schreiner, J; Schulz, O; Schuster, M; Schwarz, M; Schwingenheuer, B; Selivanenko, O; Shaflee, M; Shevchik, E; Shirchenko, M; Shitov, Y; Simgen, H; Simkovic, F; Skorokhvatov, M; Slavickova, M; Smolek, K; Smolnikov, A; Solomon, JA; Song, G; Starosta, K; Stekl, I; Stommel, M; Stukov, D; Sumathi, RR; Sweigart, DA; Szczepaniec, K; Taffarello, L; Tagnani, D; Tayloe, R; Tedeschi, D; Turqueti, M; Varner, RL; Vasilyev, S; Veresnikova, A; Vetter, K; Vignoli, C; Vogl, C; Sturm, K von; Waters, D; Waters, JC; Wei, W; Wiesinger, C; Wilkerson, JF; Willers, M; Wiseman, C; Wojcik, M; Wu, VH-S; Xu, W; Yakushev, E; Ye, T; Yu, C-H; Yumatov, V; Zaretski, N; Zeman, J; Zhitnikov, I; Zinatulina, D; Zschocke, A-K; Zsigmond, AJ; Zuber, K; Zuzel, GWe propose the construction of LEGEND-1000, the ton-scale Large Enriched Germanium Experiment for Neutrinoless $\beta \beta$ Decay. This international experiment is designed to answer one of the highest priority questions in fundamental physics. It consists of 1000 kg of Ge detectors enriched to more than 90% in the $^{76}$Ge isotope operated in a liquid argon active shield at a deep underground laboratory. By combining the lowest background levels with the best energy resolution in the field, LEGEND-1000 will perform a quasi-background-free search and can make an unambiguous discovery of neutrinoless double-beta decay with just a handful of counts at the decay $Q$ value. The experiment is designed to probe this decay with a 99.7%-CL discovery sensitivity in the $^{76}$Ge half-life of $1.3\times10^{28}$ years, corresponding to an effective Majorana mass upper limit in the range of 9-21 meV, to cover the inverted-ordering neutrino mass scale with 10 yr of live time.