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Item Open Access Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.(Pain Med, 2016-01) Naylor, Jennifer C; Kilts, Jason D; Szabo, Steven T; Dunn, Charlotte E; Keefe, Francis J; Tupler, Larry A; Shampine, Lawrence J; Morey, Rajendra A; Strauss, Jennifer L; Hamer, Robert M; Wagner, H Ryan; MIRECC Workgroup; Marx, Christine EBACKGROUND AND OBJECTIVES: Pain symptoms are common among Iraq/Afghanistan-era veterans, many of whom continue to experience persistent pain symptoms despite multiple pharmacological interventions. Preclinical data suggest that neurosteroids such as allopregnanolone demonstrate pronounced analgesic properties, and thus represent logical biomarker candidates and therapeutic targets for pain. Allopregnanolone is also a positive GABAA receptor modulator with anxiolytic, anticonvulsant, and neuroprotective actions in rodent models. We previously reported inverse associations between serum allopregnanolone levels and self-reported pain symptom severity in a pilot study of 82 male veterans. METHODS: The current study investigates allopregnanolone levels in a larger cohort of 485 male Iraq/Afghanistan-era veterans to attempt to replicate these initial findings. Pain symptoms were assessed by items from the Symptom Checklist-90-R (SCL-90-R) querying headache, chest pain, muscle soreness, and low back pain over the past 7 days. Allopregnanolone levels were quantified by gas chromatography/mass spectrometry. RESULTS: Associations between pain ratings and allopregnanolone levels were examined with Poisson regression analyses, controlling for age and smoking. Bivariate nonparametric Mann–Whitney analyses examining allopregnanolone levels across high and low levels of pain were also conducted. Allopregnanolone levels were inversely associated with muscle soreness [P = 0.0028], chest pain [P = 0.032], and aggregate total pain (sum of all four pain items) [P = 0.0001]. In the bivariate analyses, allopregnanolone levels were lower in the group reporting high levels of muscle soreness [P = 0.001]. CONCLUSIONS: These findings are generally consistent with our prior pilot study and suggest that allopregnanolone may function as an endogenous analgesic. Thus, exogenous supplementation with allopregnanolone could have therapeutic potential. The characterization of neurosteroid profiles may also have biomarker utility.Item Open Access Bullets in Envelopes: Iraqi Academics in Exile(2017) Yako, LouisIraqi academics have had a pivotal role in shaping and building Iraqi society, identity, and national structures, since the country’s independence from British colonial rule. Following the U.S. invasion of Iraq in 2003, a significant number of academics were assassinated and forced into exile and internal displacement. Since this population has always been intertwined with the state and different regimes of power, they are uniquely-situated to provide critical and multifaceted analyses on politics, the intertwined relationship between academics and power, and the complexity of exile. Through what I call a “genealogy of loss,” this ethnography traces the academic, political, and social lives of academics in contemporary Iraq to uncover the losses this population-and the Iraqi people- have incurred in contemporary Iraq. Beginning with the period from the ascendancy of the Ba‘ath Party in 1968, to the U.S.-led invasion in 2003 and up to the present, I examine the lives of Iraq’s exiled academics in three sites: the UK, Jordan, and Iraqi Kurdistan. I first examine their experience during the Ba‘ath era to explore their work, struggles, and hardships, as they made significant contributions to building their society and nation. I attempt to provide a nuanced anthropological account of life under the Ba‘ath regime and its ideals and complex realities. The second part examines these academics’ post-US occupation experiences both inside Iraq and in exile. I argue that the reconfiguration of the Iraqi state, and the shift from a secular, unified, one-party system into a divided space ruled by the occupying forces and their appointed sectarian and ethno-nationalist leaders and militia groups, has reconfigured the role of the academic and of higher education. The occupation and the subsequent Iraqi governments used death threats and assassinations, sectarianism, and “de-Ba‘athification” as forms of governance to restructure society. Many academics and professionals were either assassinated or forced into exile by sending them bullets and threat notes in envelopes. I explore how academics’ relatively stable jobs in pre-invasion Iraq are now “contracted lives” with devastating effects on their personal lives, intellectual projects, and the future of Iraq. Such lives entail living in spaces under precarious and temporary contracts and with residency cards subject to annual renewal or termination. These academics now live in constant fear and what I call a “plan B mode of existence.” While an extreme and violent case, this ethnography argues that the conditions of Iraqi academics in exile are connected to neoliberal global trends marked by the commercialization and corporatization of higher education, adversely affecting academic, social, and political freedoms of writing, thinking, and being in this world.
Item Open Access Disruptive Events and Global Jihad Over Time(2020-03) Buchanan, MatthewYears of scholarship have produced academic models to evaluate pathways to radicalization and have attempted to explain individual risk factors for radicalization. However, these studies do not consider how changes to sociopolitical conditions over time affect and drive jihad. Using data from the Western Jihadism Project (WJP), I drafted a timeline (Figure 4.1) from the Soviet invasion of Afghanistan to the present that overlays a polygon depicting the frequency of plots against Western targets with selected disruptive events. To conduct my analysis of each disruptive event included on the timeline, I created a chain of influence model (Figure 3.2). The model incorporates my research, Judea Pearl’s causal models (2018), and the North Carolina State University Lab for Analytic Science’s (NC State-LAS) Radicalization Working Group’s (RWG) socioecological model. The model also serves as my recommended inclusion criteria for events on the timeline. By testing my model on each disruptive event, I found the following: 1. The Soviet occupation of Afghanistan’s importance cannot be underestimated as a driving/enabling force in the formation of Al-Qaeda and the global jihad ideology. 2. The United States-led coalition’s involvement in repelling Iraqi forces from Kuwait strengthened the West versus Islam narrative. 3. The September 11, 2001 attacks were inspirational for global jihad; triggering an increase in the number of plots targeting the West. 4. The United States invasion of Iraq temporarily decreased plots targeting the West, but led to increased plots in Europe and the Islamic State’s formation in the long-term. 5. The information technology boom beginning in 2007 so effectively enables my model’s mechanism of influence, it merits inclusion on the timeline. 6. The Islamic State became its own disruptive event, though its continued influence remains to be seen. My findings and the trends identified on the timeline emphasize the need for policy makers to consider jihadi’s perception of disruptive events when deciding how to respond to such events. Finally, while my chain of influence model is used as an explanatory model in this paper, it has promise as a predictive model for analyzing global jihad’s potential responses to future disruptive events.Item Open Access Killing Iraq: A look at agency and power in relation to the U.S. mainstream media(2009-05-01T15:15:25Z) Ighile, Osagie