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Efficacy and Safety of a Pegasparaginase-Based Chemotherapy Regimen vs an L-asparaginase-Based Chemotherapy Regimen for Newly Diagnosed Advanced Extranodal Natural Killer/T-Cell Lymphoma: A Randomized Clinical Trial.
(JAMA oncology, 2022-06-16)<h4>Importance</h4>The L-asparaginase-based SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy regimen has shown higher response rates and survival benefit over an anthracycline-containing ... -
The third-generation anti-CD30 CAR T-cells specifically homing to the tumor and mediating powerful antitumor activity.
(Scientific reports, 2022-06-21)CAR T-cell therapy is well tolerated and effective in patients with Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). However, even second- generation anti-CD30 CAR T-cells with CD28 (28z) costimulatory domains ... -
Expanding anti-CD38 immunotherapy for lymphoid malignancies.
(Journal of experimental & clinical cancer research : CR, 2022-06-28)<h4>Background</h4>Lymphoid neoplasms, including multiple myeloma (MM), non-Hodgkin lymphoma (NHL), and NK/T cell neoplasms, are a major cause of blood cancer morbidity and mortality. CD38 (cyclic ADP ribose hydrolase) is ... -
Role of hyaluronan and hyaluronan-binding proteins in human asthma.
(The Journal of allergy and clinical immunology, 2011-08)<h4>Background</h4>The characteristics of human asthma are chronic inflammation and airway remodeling. Hyaluronan, a major extracellular matrix component, accumulates during inflammatory lung diseases, including asthma. ... -
Asthma medication usage is significantly reduced following bariatric surgery.
(Surgical endoscopy, 2019-06)<h4>Introduction</h4>Asthma is an important healthcare problem affecting millions in the United States. Additionally, a large proportion of patients with asthma suffer from obesity. These patients exhibit poor asthma control ...
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