Skip to main content
Duke University Libraries
DukeSpace Scholarship by Duke Authors
  • Login
  • Ask
  • Menu
  • Login
  • Ask a Librarian
  • Search & Find
  • Using the Library
  • Research Support
  • Course Support
  • Libraries
  • About
View Item 
  •   DukeSpace
  • Theses and Dissertations
  • Masters Theses
  • View Item
  •   DukeSpace
  • Theses and Dissertations
  • Masters Theses
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

A One Health Perspective on Disease Dynamics: Human Monkeypox Transmission in Sankuru District, Democratic Republic of Congo

Thumbnail
View / Download
1.3 Mb
Date
2015
Author
McMullen, Chelsea Lee
Advisor
Woods, Christopher W
Repository Usage Stats
386
views
369
downloads
Abstract

Background: Reports from the first monkeypox (MPX) active surveillance program in the Democratic Republic of Congo (DRC) in the 1980s determined that the disease was not of epidemic potential, with R0<1. However, during an active surveillance period from 2005-2007, researchers found a 20-fold increase during the last 30 years. The purpose of this study was to analyze the contact data from 2005-07 and compare characteristics to those of the 1980s, and toassess the change in R0 of MPX. Methods: Contact tracing information and samples from active lesions were collected. Samples were screened by PCR and positive cases were ranked by generation and grouped into chains of transmission according to date of rash onset, contact tracing, and location. R0 was determined using calculations provided in the 1980s study and chain size distribution was compared. Results: Of 1407 suspected cases of MPX investigated in 2005-07, 287 provided contact information with an average of 6.22 (range, 1-20) contacts each. Among the 703 positive cases, 408 distinct chains of transmission were identified. Average chain size was 1.75 cases (range, 1-12), with the longest reaching six generations. The crude secondary attack rate (AR) was 0.092, with an effective R0 of 0.576. Discussion: Contact characteristics and types of contacts differed from those of the 1980s program. This analysis found a higher crude secondary attack rate and effective R0. This could be the result of a higher proportion of unvaccinated contacts, or that the virus is better able to transmit between humans with a more limited amount of contact.

Type
Master's thesis
Department
Global Health
Subject
Epidemiology
Animal diseases
Public health
contact tracing
monkeypox
network analysis
reproductive rate
Permalink
https://hdl.handle.net/10161/10046
Citation
McMullen, Chelsea Lee (2015). A One Health Perspective on Disease Dynamics: Human Monkeypox Transmission in Sankuru District, Democratic Republic of Congo. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/10046.
Collections
  • Masters Theses
More Info
Show full item record
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Rights for Collection: Masters Theses


Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info

Make Your Work Available Here

How to Deposit

Browse

All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

My Account

LoginRegister

Statistics

View Usage Statistics
Duke University Libraries

Contact Us

411 Chapel Drive
Durham, NC 27708
(919) 660-5870
Perkins Library Service Desk

Digital Repositories at Duke

  • Report a problem with the repositories
  • About digital repositories at Duke
  • Accessibility Policy
  • Deaccession and DMCA Takedown Policy

TwitterFacebookYouTubeFlickrInstagramBlogs

Sign Up for Our Newsletter
  • Re-use & Attribution / Privacy
  • Harmful Language Statement
  • Support the Libraries
Duke University