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Systematic review and metasummary of attitudes toward research in emergency medical conditions

dc.contributor.author Limkakeng, Alexander T
dc.contributor.author de Oliveira, Lucas Lentini Herling
dc.contributor.author Moreira, Tais
dc.contributor.author Phadtare, Amruta
dc.contributor.author Garcia Rodrigues, Clarissa
dc.contributor.author Hocker, Michael B
dc.contributor.author McKinney, Ross
dc.contributor.author Voils, Corrine I
dc.contributor.author Pietrobon, Ricardo
dc.date.accessioned 2015-07-15T14:54:12Z
dc.date.issued 2014-01-01
dc.identifier.issn 0306-6800
dc.identifier.uri https://hdl.handle.net/10161/10308
dc.description.abstract Emergency departments are challenging research settings, where truly informed consent can be difficult to obtain. A deeper understanding of emergency medical patients' opinions about research is needed. We conducted a systematic review and meta-summary of quantitative and qualitative studies on which values, attitudes, or beliefs of emergent medical research participants influence research participation. We included studies of adults that investigated opinions toward emergency medicine research participation. We excluded studies focused on the association between demographics or consent document features and participation and those focused on non-emergency research. In August 2011, we searched the following databases: MEDLINE, EMBASE, Google Scholar, Scirus, PsycINFO, AgeLine and Global Health. Titles, abstracts and then full manuscripts were independently evaluated by two reviewers. Disagreements were resolved by consensus and adjudicated by a third author. Studies were evaluated for bias using standardised scores. We report themes associated with participation or refusal. Our initial search produced over 1800 articles. A total of 44 articles were extracted for full-manuscript analysis, and 14 were retained based on our eligibility criteria. Among factors favouring participation, altruism and personal health benefit had the highest frequency. Mistrust of researchers, feeling like a 'guinea pig' and risk were leading factors favouring refusal. Many studies noted limitations of informed consent processes in emergent conditions. We conclude that highlighting the benefits to the participant and society, mitigating risk and increasing public trust may increase research participation in emergency medical research. New methods for conducting informed consent in such studies are needed.
dc.publisher BMJ
dc.relation.ispartof Journal of Medical Ethics
dc.relation.isversionof 10.1136/medethics-2012-101147
dc.title Systematic review and metasummary of attitudes toward research in emergency medical conditions
dc.type Journal article
duke.contributor.id McKinney, Ross|0116343
duke.contributor.id Voils, Corrine I|0296655
pubs.begin-page 401
pubs.end-page 408
pubs.issue 6
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Faculty
pubs.organisational-group Medicine
pubs.organisational-group Medicine, General Internal Medicine
pubs.organisational-group Pediatrics
pubs.organisational-group Pediatrics, Infectious Diseases
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery
pubs.organisational-group Surgery, Emergency Medicine
pubs.publication-status Published
pubs.volume 40
dc.identifier.eissn 1473-4257


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