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In vivo visualization of abdominal malignancies with acoustic radiation force elastography.
Abstract
The utility of acoustic radiation force impulse (ARFI) imaging for real-time visualization
of abdominal malignancies was investigated. Nine patients presenting with suspicious
masses in the liver (n = 7) or kidney (n = 2) underwent combined sonography/ARFI imaging.
Images were acquired of a total of 12 tumors in the nine patients. In all cases, boundary
definition in ARFI images was improved or equivalent to boundary definition in B-mode
images. Displacement contrast in ARFI images was superior to echo contrast in B-mode
images for each tumor. The mean contrast for suspected hepatocellular carcinomas (HCCs)
in B-mode images was 2.9 dB (range: 1.5-4.2) versus 7.5 dB (range: 3.1-11.9) in ARFI
images, with all HCCs appearing more compliant than regional cirrhotic liver parenchyma.
The mean contrast for metastases in B-mode images was 3.1 dB (range: 1.2-5.2) versus
9.3 dB (range: 5.7-13.9) in ARFI images, with all masses appearing less compliant
than regional non-cirrhotic liver parenchyma. ARFI image contrast (10.4 dB) was superior
to B-mode contrast (0.9 dB) for a renal mass. To our knowledge, we present the first
in vivo images of abdominal malignancies in humans acquired with the ARFI method or
any other technique of imaging tissue elasticity.
Type
Journal articleSubject
Abdominal NeoplasmsAcoustics
Aged
Aged, 80 and over
Biophysical Phenomena
Biophysics
Carcinoma, Hepatocellular
Elasticity Imaging Techniques
Female
Humans
Kidney Neoplasms
Liver Neoplasms
Male
Middle Aged
Tomography, X-Ray Computed
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https://hdl.handle.net/10161/10363Published Version (Please cite this version)
10.1088/0031-9155/53/1/020Publication Info
Fahey, BJ; Nelson, RC; Bradway, DP; Hsu, SJ; Dumont, DM; & Trahey, GE (2008). In vivo visualization of abdominal malignancies with acoustic radiation force elastography.
Phys Med Biol, 53(1). pp. 279-293. 10.1088/0031-9155/53/1/020. Retrieved from https://hdl.handle.net/10161/10363.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
David Bradway
Research Scientist, Senior
David P. Bradway is a research scientist in the Biomedical Engineering Department at
Duke University. He earned his Ph.D. in biomedical engineering in 2013 from Duke.
Afterward, he was a guest postdoc at the Technical University of Denmark (DTU), supported
by a Whitaker International Program Scholarship. He has conducted research internships
at the Cleveland Clinic Foundation, Volcano Corporation, and Siemens Healthcare, working
on ultrasound research since 2002.
Rendon C. Nelson
Consulting Associate in the Department of Radiology
Diagnostic Imaging of the Liver; Specifically the Detection and Characterization of
Focal and Diffuse Processes by US, CT and MRI. Percutaneous Image-Guided Thermal Ablation
of Hepatic and Renal Tumors
Gregg E. Trahey
Robert Plonsey Distinguished Professor of Biomedical Engineering
My laboratory develops and evaluates novel ultrasonic imaging methods. Current projects
involve high resolutioon imaging of the breast and mechanical characterization of
the breast and cardiovascular system. We conduct phantom, animal, ex vivo and in
vivo trials. Current clinical trials involve imaging of soft and hard vascular plaques
and mecahnical imaging of breast lesions.
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