Impact of 5-year weight change on blood pressure: Results from the weight loss maintenance trial
Abstract
In this secondary analysis of the Weight Loss Maintenance trial, the authors assessed
the relationship between blood pressure (BP) change and weight change in overweight
and obese adults with hypertension and/or dyslipidemia who were randomized to 1 of
3 weight loss maintenance strategies for 5 years. The participants were grouped (N=741)
based on weight change from randomization to 60 months as: (1) weight loss, (2) weight
stable, or (3) weight gain. A significant positive correlation between weight change
and systolic BP (SBP) change at 12, 30, and 60 months and between weight change and
diastolic BP (DBP) change at 30 months was observed. From randomization to 60 months,
mean SBP increased to a similar degree for the weight gain group (4.2±standard error=0.6
mm Hg; P<.001) and weight stable group (4.6±1.1 mm Hg; P<.001), but SBP did
not rise in the weight loss group (1.0±1.7 mm Hg, P=53). DBP was unchanged for all
groups at 60 months. Although aging may have contributed to rise in BP at 60 months,
it does not appear to fully account for observed BP changes. These results suggest
that continued modest weight loss may be sufficient for long-term BP lowering. © 2013
Wiley Periodicals, Inc.
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Journal articlePermalink
https://hdl.handle.net/10161/10734Published Version (Please cite this version)
10.1111/jch.12108Publication Info
Tyson, Crystal C; Appel, Lawrence J; Vollmer, William M; Jerome, Gerald J; Brantley,
Phillip J; Hollis, Jack F; ... Svetkey, Laura P (2013). Impact of 5-year weight change on blood pressure: Results from the weight loss maintenance
trial. Journal of Clinical Hypertension, 15(7). pp. 458-464. 10.1111/jch.12108. Retrieved from https://hdl.handle.net/10161/10734.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Uptal Dinesh Patel
Adjunct Professor in the Department of Medicine
Uptal Patel, MD is an Adjunct Professor interested in population health with a broad
range of clinical and research experience. As an adult and pediatric nephrologist
with training in health services and epidemiology, his work seeks to improve population
health for patients with kidney diseases through improvements in prevention, diagnosis
and treatment. Prior efforts focused on four inter-related areas that are essential
to improving kidney health: i) reducing the progressi
Laura Pat Svetkey
Professor of Medicine
Laura P. Svetkey, MD MHS is Professor of Medicine/Nephrology, Vice Chair for Faculty
Development and Diversity in the Department of Medicine. She is also the Director
of Duke’s CTSA-sponsored internal career development award program (KL2) and the Associate
Director of Duke’s REACH Equity Disparities Research Center, in which she also leads
the Investigator Development Core.
Dr. Svetkey has over 30 years of experience in the investigation of hypertens
Crystal Cenell Tyson
Assistant Professor of Medicine
As a board-certified nephrologist and a certified clinical hypertension specialist
(ASH-SCH), I take care of patients with kidney disorders and/or high blood pressure.
Patients with chronic kidney disease and high blood pressure have an increased risk
for developing complications of cardiovascular disease, such as heart attacks, congestive
heart failure, strokes, kidney failure requiring dialysis or a kidney transplant,
and a shortened lifespan. My clinical focus is to slow the progression of
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