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Cumulative stress in childhood is associated with blunted reward-related brain activity in adulthood.

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Date
2016-03
Authors
Hanson, JL
Albert, WD
Iselin, AR
Carré, JM
Dodge, KA
Hariri, AR
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472
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Abstract
Early life stress (ELS) is strongly associated with negative outcomes in adulthood, including reduced motivation and increased negative mood. The mechanisms mediating these relations, however, are poorly understood. We examined the relation between exposure to ELS and reward-related brain activity, which is known to predict motivation and mood, at age 26, in a sample followed since kindergarten with annual assessments. Using functional neuroimaging, we assayed individual differences in the activity of the ventral striatum (VS) during the processing of monetary rewards associated with a simple card-guessing task, in a sample of 72 male participants. We examined associations between a cumulative measure of ELS exposure and VS activity in adulthood. We found that greater levels of cumulative stress during childhood and adolescence predicted lower reward-related VS activity in adulthood. Extending this general developmental pattern, we found that exposure to stress early in development (between kindergarten and grade 3) was significantly associated with variability in adult VS activity. Our results provide an important demonstration that cumulative life stress, especially during this childhood period, is associated with blunted reward-related VS activity in adulthood. These differences suggest neurobiological pathways through which a history of ELS may contribute to reduced motivation and increased negative mood.
Type
Journal article
Subject
early life stress
fMRI
neurodevelopment
reward
ventral striatum
Adolescent
Adult
Affect
Brain
Child
Child, Preschool
Humans
Individuality
Magnetic Resonance Imaging
Male
Motivation
Reward
Stress, Psychological
Ventral Striatum
Permalink
https://hdl.handle.net/10161/10777
Published Version (Please cite this version)
10.1093/scan/nsv124
Publication Info
Hanson, JL; Albert, WD; Iselin, AR; Carré, JM; Dodge, KA; & Hariri, AR (2016). Cumulative stress in childhood is associated with blunted reward-related brain activity in adulthood. Soc Cogn Affect Neurosci, 11(3). pp. 405-412. 10.1093/scan/nsv124. Retrieved from https://hdl.handle.net/10161/10777.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Dodge

Kenneth A. Dodge

William McDougall Distinguished Professor of Public Policy Studies
Kenneth A. Dodge is the William McDougall Distinguished Professor of Public Policy and Professor of Psychology and Neuroscience at Duke University. He is also the founding and past director of the Center for Child and Family Policy, as well as the founder of Family Connects International.  Dodge is a leading scholar in the development and prevention of aggressive and violent beha
Hariri

Ahmad Hariri

Professor of Psychology and Neuroscience
Integrating psychology, neuroimaging, pharmacology and molecular genetics in the search for biological pathways mediating individual differences in behavior and related risk for psychopathology.
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