Targeted radiotherapy of brain tumours.
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The utility of external beam radiotherapy for the treatment of malignant brain tumours is compromised by the need to avoid excessive radiation damage to normal CNS tissues. This review describes the current status of targeted radiotherapy, an alternative strategy for brain tumour treatment that offers the exciting prospect of increasing the specificity of tumour cell irradiation.
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Published Version (Please cite this version)10.1038/sj.bjc.6601771
Publication InfoZalutsky, MR (2004). Targeted radiotherapy of brain tumours. Br J Cancer, 90(8). pp. 1469-1473. 10.1038/sj.bjc.6601771. Retrieved from https://hdl.handle.net/10161/11048.
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Jonathan Spicehandler, M.D. Distinguished Professor of Neuro Oncology, in the School of Medicine
The overall objective of our laboratory is the development of novel radioactive compounds for improving the diagnosis and treatment of cancer. This work primarily involves radiohalo-genation of biomolecules via site-specific approaches, generally via demetallation reactions. Radionuclides utilized for imaging include I-123, I-124 and F-18, the later two being of particular interest because they can be used for the quantification of biochemical and physiological processes in the living huma