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Insomnia and its associations in patients with recurrent glial neoplasms.

dc.contributor.author Robertson, Matthew E
dc.contributor.author McSherry, Frances
dc.contributor.author Herndon, James E
dc.contributor.author Peters, Katherine B
dc.coverage.spatial Switzerland
dc.date.accessioned 2016-12-01T14:21:00Z
dc.date.issued 2016
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/27390663
dc.identifier 2578
dc.identifier.uri https://hdl.handle.net/10161/13036
dc.description.abstract BACKGROUND: Patient with neurological disorders and cancer can develop sleep disturbance, in particular insomnia. Etiology of insomnia is multi-factorial in primary brain tumour patients with possible causes including corticosteroids, psychoactive medications, co-morbid psychiatric/medical conditions, and damage to neuronal tissue. FINDINGS: To understand better insomnia in recurrent glioma patients, a single-center retrospective analysis was performed looking at recurrent glioma patients from January 2004 to May 2009. Data was extracted and included demographics, clinical factors, psychoactive medications, and co-morbid symptoms. Presence and absence of insomnia complaints was evaluated with other co-morbidities using Chi square and Wilcoxon analyses. Records from 340 recurrent glioma patients were evaluated and 46.8 % (n = 159) indicated presence of insomnia with 20 % (n = 66) actively using medications for sleep. Use of corticosteroids were significantly associated with insomnia (p = 0.0003). Age, gender, tumour location, use of stimulants, antipsychotics, and antidepressants were not significantly associated with insomnia in recurrent glioma patients. There was a trend towards a possible significant association with insomnia to fatigue complaints and use of anti-epileptics, p-values of 0.0501 and 0.0725 respectively. CONCLUSIONS: In conclusion, insomnia is commonly encountered in patients with recurrent glial tumors. Corticosteroid use is associated with insomnia in this population. In light of the frequency of insomnia and its associations, future analysis is warranted into sleep complaints in recurrent glioma patients and its impact on quality of life.
dc.language eng
dc.publisher Springer Science and Business Media LLC
dc.relation.ispartof Springerplus
dc.relation.isversionof 10.1186/s40064-016-2578-6
dc.subject Glial
dc.subject Insomnia
dc.subject Neoplasms
dc.subject Recurrent
dc.title Insomnia and its associations in patients with recurrent glial neoplasms.
dc.type Journal article
duke.contributor.id Herndon, James E|0112010
duke.contributor.id Peters, Katherine B|0483454
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/27390663
pubs.begin-page 823
pubs.issue 1
pubs.organisational-group Basic Science Departments
pubs.organisational-group Biostatistics & Bioinformatics
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Neurology
pubs.organisational-group Neurology, General & Community Neurology
pubs.organisational-group Neurosurgery
pubs.organisational-group School of Medicine
pubs.publication-status Published online
pubs.volume 5


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