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RNA-Based Vaccines in Cancer Immunotherapy.

dc.contributor.author McNamara, Megan A
dc.contributor.author Nair, Smita K
dc.contributor.author Holl, Eda K
dc.coverage.spatial Egypt
dc.date.accessioned 2017-06-16T19:51:12Z
dc.date.available 2017-06-16T19:51:12Z
dc.date.issued 2015
dc.identifier https://www.ncbi.nlm.nih.gov/pubmed/26665011
dc.identifier.uri https://hdl.handle.net/10161/14926
dc.description.abstract RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription using a bacteriophage RNA polymerase and template DNA that encodes the antigen(s) of interest. Once administered and internalized by host cells, the mRNA transcripts are translated directly in the cytoplasm and then the resulting antigens are presented to antigen presenting cells to stimulate an immune response. Alternatively, dendritic cells can be loaded with either tumor associated antigen mRNA or total tumor RNA and delivered to the host to elicit a specific immune response. In this review, we will explain why RNA vaccines represent an attractive platform for cancer immunotherapy, discuss modifications to RNA structure that have been developed to optimize mRNA vaccine stability and translational efficiency, and describe strategies for nonviral delivery of mRNA vaccines, highlighting key preclinical and clinical data related to cancer immunotherapy.
dc.language eng
dc.publisher Hindawi Limited
dc.relation.ispartof J Immunol Res
dc.relation.isversionof 10.1155/2015/794528
dc.subject Animals
dc.subject Antigen Presentation
dc.subject Antigens, Neoplasm
dc.subject Cancer Vaccines
dc.subject Clinical Trials as Topic
dc.subject Cytotoxicity, Immunologic
dc.subject Dendritic Cells
dc.subject Disease Models, Animal
dc.subject Humans
dc.subject Lymphocyte Activation
dc.subject Neoplasms
dc.subject RNA, Messenger
dc.title RNA-Based Vaccines in Cancer Immunotherapy.
dc.type Journal article
duke.contributor.id Nair, Smita K|0114773
duke.contributor.id Holl, Eda K|0456028
pubs.author-url https://www.ncbi.nlm.nih.gov/pubmed/26665011
pubs.begin-page 794528
pubs.organisational-group Clinical Science Departments
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Pathology
pubs.organisational-group School of Medicine
pubs.organisational-group Surgery
pubs.organisational-group Surgery, Surgical Sciences
pubs.publication-status Published
pubs.volume 2015
dc.identifier.eissn 2314-7156
duke.contributor.orcid Nair, Smita K|0000-0001-7019-1912
duke.contributor.orcid Holl, Eda K|0000-0002-6975-3647


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