The role of stem cells in airway repair: implications for the origins of lung cancer.
Abstract
Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, advancements
in our ability to identify and study stem cell populations in the lung have helped
researchers to elucidate the central role that cells with stem cell-like properties
may have in lung tumorigenesis. Much of this research has focused on the use of the
airway repair model to study response to injury. In this review, we discuss the primary
evidence of the role that cancer stem cells play in lung cancer development. The implications
of a stem cell origin of lung cancer are reviewed, and the importance of ongoing research
to identify novel therapeutic and prognostic targets is reiterated.
Type
Journal articleSubject
AnimalsCarcinoma, Non-Small-Cell Lung
Cell Transformation, Neoplastic
Humans
Lung Injury
Lung Neoplasms
Neoplastic Stem Cells
Regeneration
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https://hdl.handle.net/10161/15040Published Version (Please cite this version)
10.5732/cjc.012.10097Publication Info
Mulvihill, Michael S; Kratz, Johannes R; Pham, Patrick; Jablons, David M; & He, Biao (2013). The role of stem cells in airway repair: implications for the origins of lung cancer.
Chin J Cancer, 32(2). pp. 71-74. 10.5732/cjc.012.10097. Retrieved from https://hdl.handle.net/10161/15040.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Michael Mulvihill
House Staff

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