Retinal representation of the elementary visual signal.
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The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording from multiple retinal ganglion cells of identified types. The visual signal initiated by an individual cone produced strong responses with different kinetics in three of the four numerically dominant ganglion cell types. The magnitude and kinetics of light responses in each ganglion cell varied nonlinearly with stimulus strength but in a manner that was independent of the cone of origin after accounting for the overall input strength of each cone. Based on this property of independence, the receptive field profile of an individual ganglion cell could be well estimated from responses to stimulation of each cone individually. Together, these findings provide a quantitative account of how elementary visual inputs form the ganglion cell receptive field.
Retinal Ganglion Cells
Retinal Cone Photoreceptor Cells
In Vitro Techniques
Published Version (Please cite this version)10.1016/j.neuron.2013.10.043
Publication InfoField, Greg; Li, Peter H; Greschner, Martin; Ahn, Daniel; Gunning, Deborah E; Mathieson, Keith; ... Chichilnisky, EJ (2014). Retinal representation of the elementary visual signal. Neuron, 81(1). pp. 130-139. 10.1016/j.neuron.2013.10.043. Retrieved from https://hdl.handle.net/10161/17867.
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Assistant Professor of Neurobiology
My laboratory studies how the retina processes visual scenes and transmits this information to the brain. We use multi-electrode arrays to record the activity of hundreds of retina neurons simultaneously in conjunction with transgenic mouse lines and chemogenetics to manipulate neural circuit function. We are interested in three major areas. First, we work to understand how neurons in the retina are functionally connected. Second we are studying how light-adaptation and circadian rhythms a