Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.
Abstract
Some TGFB1 and VEGF polymorphisms are believed to be functional. Given that these
genes are involved in tumor growth and progression including angiogenesis, dissemination,
and invasiveness, we hypothesized that these polymorphisms would be associated with
survival in patients with gastric cancer.We genotyped TGFB1 -509 C>T, +1869 T>C, and
+915 G>C and VEGF -1498T>C, -634G>C, and +936C>T in 167 patients with gastric cancer.
Using the Kaplan and Meier method, log-rank tests, and Cox proportional hazard models,
we evaluated associations among TGFB1 and VEGF variants with overall, 1-year, and
2-year survival rates.Although there were no significant differences in overall survival
rates among all polymorphisms tested, patients with TGFB1+915CG and CC genotypes had
a poorer 2-year survival (adjusted hazard ratio (HR), 3.06; 95% confidence interval
(CI), 1.09-8.62; P = 0.034) than patients with the GG genotype had. In addition, patients
heterozygous for VEGF -634CG also had a poorer 1-year survival (adjusted HR, 2.08;
95% CI, 1.03-4.22; P = 0.042) than patients with the -634GG genotype.Our study suggested
that TGFB1+915CG/CC and VEGF -634CG genotypes may be associated with short-term survival
in gastric cancer patients. However, larger studies are needed to verify these findings.
Type
Journal articleSubject
HumansStomach Neoplasms
Vascular Endothelial Growth Factor A
Survival Rate
Proportional Hazards Models
Prospective Studies
Genotype
Haplotypes
Linkage Disequilibrium
Polymorphism, Genetic
Aged
Middle Aged
Male
Transforming Growth Factor beta1
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https://hdl.handle.net/10161/17967Published Version (Please cite this version)
10.1186/1756-9966-28-94Publication Info
Guan, Xiaoxiang; Zhao, Hui; Niu, Jiangong; Tan, Dongfeng; Ajani, Jaffer A; & Wei,
Qingyi (2009). Polymorphisms of TGFB1 and VEGF genes and survival of patients with gastric cancer.
Journal of experimental & clinical cancer research : CR, 28(1). pp. 94. 10.1186/1756-9966-28-94. Retrieved from https://hdl.handle.net/10161/17967.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Qingyi Wei
Professor in Population Health Sciences
Qingyi Wei, MD, PhD, Professor in the Department of Medicine, is Associate Director
for Cancer Control and Population Sciences, Co-leader of CCPS and Co-leader of Epidemiology
and Population Genomics (Focus Area 1). He is a professor of Medicine and an internationally
recognized epidemiologist focused on the molecular and genetic epidemiology of head
and neck cancers, lung cancer, and melanoma. His research focuses on biomarkers and
genetic determinants for the DNA repair deficient phenotype and

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