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MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.

dc.contributor.author Song, Xicheng
dc.contributor.author Sturgis, Erich M
dc.contributor.author Liu, Jun
dc.contributor.author Jin, Lei
dc.contributor.author Wang, Zhongqiu
dc.contributor.author Zhang, Caiyun
dc.contributor.author Wei, Qingyi
dc.contributor.author Li, Guojun
dc.date.accessioned 2019-02-01T15:14:57Z
dc.date.available 2019-02-01T15:14:57Z
dc.date.issued 2013-01
dc.identifier PONE-D-12-29884
dc.identifier.issn 1932-6203
dc.identifier.issn 1932-6203
dc.identifier.uri https://hdl.handle.net/10161/17995
dc.description.abstract Both microRNAs and human papillomavirus (HPV) infection play an important role in the development and progression of oral squamous cell carcinoma (OSCC). In addition, microRNAs affect all facets of the immune/inflammation responses to infection, which may control HPV clearance. We thus hypothesized that microRNA polymorphisms modify the association between HPV16 seropositivity and OSCC risk.Four single-nucleotide polymorphisms in microRNAs were genotyped and HPV16 serology was determined in 325 cases and 335 matched controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using univariate and multivariable logistic regression models.Overall, each polymorphism had no significant main effect on OSCC risk. Compared with the risk among individuals with both miR146 rs2910164 GG genotype and HPV16 seronegativity, risk of OSCC was increased among those with CG or CC genotype and HPV16 seronegativity (OR, 1.2; 95% CI, 0.9-1.8), GG genotype and HPV16 seropositivity (OR, 3.0; 95% CI, 1.8-5.0), and CG or CC genotype and HPV16 seropositivity (OR, 4.7; 95% CI, 2.3-9.4). Similar results were found for miR149 rs2292832, miR196 rs11614913, and miR499 rs3746444. Analyses stratified by tumor sites and smoking status showed that each polymorphism significantly increased the risk of HPV16-associated squamous cell carcinoma of the oropharynx (SCCOP), and such effect modification was particularly prominent in never smokers.Our results indicate that microRNA polymorphisms modify the risk of OSCC associated with HPV16 seropositivity, particularly in patients with SCCOP and never smokers. Larger studies are needed to verify our findings.
dc.language eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PloS one
dc.relation.isversionof 10.1371/journal.pone.0056622
dc.subject Humans
dc.subject Carcinoma, Squamous Cell
dc.subject Oropharyngeal Neoplasms
dc.subject Genetic Predisposition to Disease
dc.subject MicroRNAs
dc.subject Serologic Tests
dc.subject Smoking
dc.subject Polymorphism, Single Nucleotide
dc.subject Adult
dc.subject Aged
dc.subject Middle Aged
dc.subject Female
dc.subject Male
dc.subject Human papillomavirus 16
dc.title MicroRNA variants increase the risk of HPV-associated squamous cell carcinoma of the oropharynx in never smokers.
dc.type Journal article
duke.contributor.id Wei, Qingyi|0632334
dc.date.updated 2019-02-01T15:14:56Z
pubs.begin-page e56622
pubs.issue 2
pubs.organisational-group School of Medicine
pubs.organisational-group Duke
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 8
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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