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Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.

dc.contributor.author Liu, Zhensheng
dc.contributor.author Wei, Qingyi
dc.contributor.author Han, Chan H
dc.contributor.author Huang, Yu-Jing
dc.contributor.author Lu, Karen H
dc.contributor.author Mills, Gordon B
dc.contributor.author Wang, Li-E
dc.date.accessioned 2019-02-01T15:25:46Z
dc.date.available 2019-02-01T15:25:46Z
dc.date.issued 2011-01-07
dc.identifier 1756-9966-30-5
dc.identifier.issn 0392-9078
dc.identifier.issn 1756-9966
dc.identifier.uri https://hdl.handle.net/10161/18017
dc.description.abstract SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ovarian cancer. We hypothesized that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic characteristics.We genotyped five common (minor allele frequency>0.05) regulatory SNPs with predicted functionalities (rs2623047 G>A, rs13264163 A>G, rs6990375 G>A, rs3802278 G>A, and rs3087714 C>T) in 168 patients with primary epithelial ovarian cancer, using the polymerase chain reaction-restriction fragment length polymorphism method.We found that rs2623047 G>A was significantly associated with an early age of onset of ovarian cancer in the G allele dose-response manner (P = 0.027; Ptrend = 0.007) and that rs2623047 GG/GA genotypes were associated with longer progression-free survival; rs6990375 G>A was also associated with the early age of onset in the A allele dose-response manner (P = 0.013; Ptrend= 0.009). The significant differences in age of disease onset persisted among carriers of haplotypes of rs2623047 and rs6990375 (P = 0.014; Ptrend = 0.004). In luciferase reporter gene assays, rs2623047 G allele showed a slightly higher promoter activity than the A allele in the SKOV3 tumorigenic cell line.These findings suggest that genetic variations in SULF1 may play a role in ovarian cancer onset and prognosis. Further studies with large sample sizes and of the mechanistic relevance of SULF1 SNPs are warranted.
dc.language eng
dc.publisher Springer Nature
dc.relation.ispartof Journal of experimental & clinical cancer research : CR
dc.relation.isversionof 10.1186/1756-9966-30-5
dc.subject Humans
dc.subject Ovarian Neoplasms
dc.subject Sulfotransferases
dc.subject Neoplasm Staging
dc.subject Age of Onset
dc.subject Polymorphism, Single Nucleotide
dc.subject Aged
dc.subject Middle Aged
dc.subject Female
dc.subject Kaplan-Meier Estimate
dc.title Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.
dc.type Journal article
dc.date.updated 2019-02-01T15:25:44Z
pubs.begin-page 5
pubs.issue 1
pubs.organisational-group Staff
pubs.organisational-group Duke
pubs.organisational-group School of Medicine
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Institutes and Centers
pubs.organisational-group Population Health Sciences
pubs.organisational-group Basic Science Departments
pubs.organisational-group Medicine, Medical Oncology
pubs.organisational-group Medicine
pubs.organisational-group Clinical Science Departments
pubs.publication-status Published
pubs.volume 30
duke.contributor.orcid Wei, Qingyi|0000-0002-3845-9445


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