dc.contributor.author |
Han, Chan H |
|
dc.contributor.author |
Huang, Yu-Jing |
|
dc.contributor.author |
Lu, Karen H |
|
dc.contributor.author |
Liu, Zhensheng |
|
dc.contributor.author |
Mills, Gordon B |
|
dc.contributor.author |
Wei, Qingyi |
|
dc.contributor.author |
Wang, Li-E |
|
dc.date.accessioned |
2019-02-01T15:25:46Z |
|
dc.date.available |
2019-02-01T15:25:46Z |
|
dc.date.issued |
2011-01-07 |
|
dc.identifier |
1756-9966-30-5 |
|
dc.identifier.issn |
0392-9078 |
|
dc.identifier.issn |
1756-9966 |
|
dc.identifier.uri |
https://hdl.handle.net/10161/18017 |
|
dc.description.abstract |
SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate,
changing the binding sites for extracellular growth factors. SULF1 expression has
been reported to be decreased in various cancers, including ovarian cancer. We hypothesized
that single nucleotide polymorphisms (SNPs) of SULF1 would impact clinicopathologic
characteristics.We genotyped five common (minor allele frequency>0.05) regulatory
SNPs with predicted functionalities (rs2623047 G>A, rs13264163 A>G, rs6990375 G>A,
rs3802278 G>A, and rs3087714 C>T) in 168 patients with primary epithelial ovarian
cancer, using the polymerase chain reaction-restriction fragment length polymorphism
method.We found that rs2623047 G>A was significantly associated with an early age
of onset of ovarian cancer in the G allele dose-response manner (P = 0.027; Ptrend
= 0.007) and that rs2623047 GG/GA genotypes were associated with longer progression-free
survival; rs6990375 G>A was also associated with the early age of onset in the A allele
dose-response manner (P = 0.013; Ptrend= 0.009). The significant differences in age
of disease onset persisted among carriers of haplotypes of rs2623047 and rs6990375
(P = 0.014; Ptrend = 0.004). In luciferase reporter gene assays, rs2623047 G allele
showed a slightly higher promoter activity than the A allele in the SKOV3 tumorigenic
cell line.These findings suggest that genetic variations in SULF1 may play a role
in ovarian cancer onset and prognosis. Further studies with large sample sizes and
of the mechanistic relevance of SULF1 SNPs are warranted.
|
|
dc.language |
eng |
|
dc.publisher |
Springer Science and Business Media LLC |
|
dc.relation.ispartof |
Journal of experimental & clinical cancer research : CR |
|
dc.relation.isversionof |
10.1186/1756-9966-30-5 |
|
dc.subject |
Humans |
|
dc.subject |
Ovarian Neoplasms |
|
dc.subject |
Sulfotransferases |
|
dc.subject |
Neoplasm Staging |
|
dc.subject |
Age of Onset |
|
dc.subject |
Polymorphism, Single Nucleotide |
|
dc.subject |
Aged |
|
dc.subject |
Middle Aged |
|
dc.subject |
Female |
|
dc.subject |
Kaplan-Meier Estimate |
|
dc.title |
Polymorphisms in the SULF1 gene are associated with early age of onset and survival
of ovarian cancer.
|
|
dc.type |
Journal article |
|
duke.contributor.id |
Liu, Zhensheng|0633329 |
|
duke.contributor.id |
Wei, Qingyi|0632334 |
|
dc.date.updated |
2019-02-01T15:25:44Z |
|
pubs.begin-page |
5 |
|
pubs.issue |
1 |
|
pubs.organisational-group |
Staff |
|
pubs.organisational-group |
Duke |
|
pubs.organisational-group |
School of Medicine |
|
pubs.organisational-group |
Duke Cancer Institute |
|
pubs.organisational-group |
Institutes and Centers |
|
pubs.organisational-group |
Population Health Sciences |
|
pubs.organisational-group |
Basic Science Departments |
|
pubs.organisational-group |
Medicine, Medical Oncology |
|
pubs.organisational-group |
Medicine |
|
pubs.organisational-group |
Clinical Science Departments |
|
pubs.publication-status |
Published |
|
pubs.volume |
30 |
|
duke.contributor.orcid |
Wei, Qingyi|0000-0002-3845-9445 |
|