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Exploring the Interface Between Therapeutically Relevant Polymers and the Immune System

dc.contributor.advisor Sullenger, Bruce A Moreno, Angelo 2019-06-07T19:48:46Z 2021-05-21T08:17:14Z 2019
dc.description Dissertation
dc.description.abstract <p>In order to ameliorate current maladies, improvements to medicaments and treatment regimens are required. Our lab seeks to translate findings from the laboratory bench to the patient bedside using two approaches: 1) the development of RNA aptamers that bind with high affinity and specificity to defined molecular targets, and 2) repurposing cationic binding polymers as anti-inflammatory agents. This dissertation herein, discusses both of these approaches and summarizes the findings obtained during my graduate training. In the first study, I illustrate how anti-PEG antibodies are capable of binding to and inhibiting a therapeutic RNA aptamer as demonstrated by reduction in drug potency in vitro and in vivo. In the second portion, the development of novel cationic polymer derivatives is discussed, which will help us to determine nucleic acid binding polymer mediated anti-inflammatory mechanisms of action. These findings shed light on the importance of careful and considered drug design to inform the development of future therapeutics. Despite the advances in translational research, there remains a paucity in our understanding of how drugs impact the immune system and this dissertation, in toto, seeks to aid in the development of improved bona fide therapies.</p>
dc.subject Microbiology
dc.subject Molecular biology
dc.subject Biochemistry
dc.subject antiinflammatory
dc.subject anti-PEG
dc.subject aptamers
dc.subject cancer
dc.subject polymers
dc.subject therapuetics
dc.title Exploring the Interface Between Therapeutically Relevant Polymers and the Immune System
dc.type Dissertation
dc.department Molecular Genetics and Microbiology
duke.embargo.months 23

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