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Design and Synthesis of Natural and Unnatural Macrocycles

dc.contributor.advisor Hong, Jiyong Lee, Hyunji 2020-02-10T17:28:14Z 2022-01-10T09:17:11Z 2019
dc.description Dissertation
dc.description.abstract <p>Macrocycles have received growing appreciation for their potential in probing a broader biological space, and there are a significant number of bioactive macrocycles in nature. In addition, a macrocyclic scaffold provides interesting features, including high binding affinity and target selectivity due to the pre-organized conformation. Despite the therapeutic potential and valuable pharmacological characteristics, this class of scaffolds has been poorly exploited in the field of drug discovery because of synthetic challenges and incompatibility to the conventional Lipinski’s rule of five. Therefore, efficient approaches for the generation of diverse and complex macrocycles are needed to develop novel macrocyclic agents.</p><p>In an attempt to construct a diverse set of macrocycles, we designed a natural product-like macrocycle library containing a tetrahydropyran core. Our strategy for the generation of the library is based on the tandem allylic oxidation/oxa-conjugate addition for the stereoselective synthesis of a 2,6-cis-tetrahydropyran ring. The incorporation of various building blocks and the utilization of diverse macrocyclization methods were carried out to rapidly increase skeletal diversity and complexity. Appendage diversification was performed to further modulate the physicochemical properties of the macrocycles. Cheminformatic analyses demonstrated that our macrocycle library covers a distinct chemical space compared to drug-like space, while significantly overlapping</p><p>with macrocyclic natural product space. </p><p>We also explored a modular strategy for the synthesis of a macrocycle from nature, forazoline A, polyketide natural product. Forazoline A exhibits potent in vivo efficacy against the fungal pathogen Candida albicans displaying a synergistic effect with amphotericin B. Our approach towards the synthesis of forazoline A relied on the construction of three major fragments with the desired stereochemistry and the assembly of those fragments. In the dissertation, the synthetic studies of cyclohexane, thiazolidine, and alkyl chain fragments were introduced. Construction of the highly functionalized cyclohexane moiety was efficiently accomplished utilizing Mukaiyama aldol, Bayer–Villeger reaction, and addition of lithium dimethyl cuprate. Synthesis of the thiazolidine fragment was investigated via oxa-conjugate addition and Pummerer-type rearrangements. Finally, the alkyl chain fragment was synthesized through epoxidation, regioselective ring opening, and β-ketoester formation.</p>
dc.subject Organic chemistry
dc.subject Chemical Library
dc.subject Macrocycle
dc.subject Polyketide
dc.subject Synthesis
dc.title Design and Synthesis of Natural and Unnatural Macrocycles
dc.type Dissertation
dc.department Chemistry
duke.embargo.months 22.980821917808218

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