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The genetic architecture of the human cerebral cortex.

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Date
2020-03
Authors
Grasby, Katrina L
Jahanshad, Neda
Painter, Jodie N
Colodro-Conde, Lucía
Bralten, Janita
Hibar, Derrek P
Lind, Penelope A
Pizzagalli, Fabrizio
Ching, Christopher RK
McMahon, Mary Agnes B
Shatokhina, Natalia
Zsembik, Leo CP
Thomopoulos, Sophia I
Zhu, Alyssa H
Strike, Lachlan T
Agartz, Ingrid
Alhusaini, Saud
Almeida, Marcio AA
Alnæs, Dag
Amlien, Inge K
Andersson, Micael
Ard, Tyler
Armstrong, Nicola J
Ashley-Koch, Allison
Atkins, Joshua R
Bernard, Manon
Brouwer, Rachel M
Buimer, Elizabeth EL
Bülow, Robin
Bürger, Christian
Cannon, Dara M
Chakravarty, Mallar
Chen, Qiang
Cheung, Joshua W
Couvy-Duchesne, Baptiste
Dale, Anders M
Dalvie, Shareefa
de Araujo, Tânia K
de Zubicaray, Greig I
de Zwarte, Sonja MC
den Braber, Anouk
Doan, Nhat Trung
Dohm, Katharina
Ehrlich, Stefan
Engelbrecht, Hannah-Ruth
Erk, Susanne
Fan, Chun Chieh
Fedko, Iryna O
Foley, Sonya F
Ford, Judith M
Fukunaga, Masaki
Garrett, Melanie E
Ge, Tian
Giddaluru, Sudheer
Goldman, Aaron L
Green, Melissa J
Groenewold, Nynke A
Grotegerd, Dominik
Gurholt, Tiril P
Gutman, Boris A
Hansell, Narelle K
Harris, Mathew A
Harrison, Marc B
Haswell, Courtney C
Hauser, Michael
Herms, Stefan
Heslenfeld, Dirk J
Ho, New Fei
Hoehn, David
Hoffmann, Per
Holleran, Laurena
Hoogman, Martine
Hottenga, Jouke-Jan
Ikeda, Masashi
Janowitz, Deborah
Jansen, Iris E
Jia, Tianye
Jockwitz, Christiane
Kanai, Ryota
Karama, Sherif
Kasperaviciute, Dalia
Kaufmann, Tobias
Kelly, Sinead
Kikuchi, Masataka
Klein, Marieke
Knapp, Michael
Knodt, Annchen R
Krämer, Bernd
Lam, Max
Lancaster, Thomas M
Lee, Phil H
Lett, Tristram A
Lewis, Lindsay B
Lopes-Cendes, Iscia
Luciano, Michelle
Macciardi, Fabio
Marquand, Andre F
Mathias, Samuel R
Melzer, Tracy R
Milaneschi, Yuri
Mirza-Schreiber, Nazanin
Moreira, Jose CV
Mühleisen, Thomas W
Müller-Myhsok, Bertram
Najt, Pablo
Nakahara, Soichiro
Nho, Kwangsik
Olde Loohuis, Loes M
Orfanos, Dimitri Papadopoulos
Pearson, John F
Pitcher, Toni L
Pütz, Benno
Quidé, Yann
Ragothaman, Anjanibhargavi
Rashid, Faisal M
Reay, William R
Redlich, Ronny
Reinbold, Céline S
Repple, Jonathan
Richard, Geneviève
Riedel, Brandalyn C
Risacher, Shannon L
Rocha, Cristiane S
Mota, Nina Roth
Salminen, Lauren
Saremi, Arvin
Saykin, Andrew J
Schlag, Fenja
Schmaal, Lianne
Schofield, Peter R
Secolin, Rodrigo
Shapland, Chin Yang
Shen, Li
Shin, Jean
Shumskaya, Elena
Sønderby, Ida E
Sprooten, Emma
Tansey, Katherine E
Teumer, Alexander
Thalamuthu, Anbupalam
Tordesillas-Gutiérrez, Diana
Turner, Jessica A
Uhlmann, Anne
Vallerga, Costanza Ludovica
van der Meer, Dennis
van Donkelaar, Marjolein MJ
van Eijk, Liza
van Erp, Theo GM
van Haren, Neeltje EM
van Rooij, Daan
van Tol, Marie-José
Veldink, Jan H
Verhoef, Ellen
Walton, Esther
Wang, Mingyuan
Wang, Yunpeng
Wardlaw, Joanna M
Wen, Wei
Westlye, Lars T
Whelan, Christopher D
Witt, Stephanie H
Wittfeld, Katharina
Wolf, Christiane
Wolfers, Thomas
Wu, Jing Qin
Yasuda, Clarissa L
Zaremba, Dario
Zhang, Zuo
Zwiers, Marcel P
Artiges, Eric
Assareh, Amelia A
Ayesa-Arriola, Rosa
Belger, Aysenil
Brandt, Christine L
Brown, Gregory G
Cichon, Sven
Curran, Joanne E
Davies, Gareth E
Degenhardt, Franziska
Dennis, Michelle F
Dietsche, Bruno
Djurovic, Srdjan
Doherty, Colin P
Espiritu, Ryan
Garijo, Daniel
Gil, Yolanda
Gowland, Penny A
Green, Robert C
Häusler, Alexander N
Heindel, Walter
Ho, Beng-Choon
Hoffmann, Wolfgang U
Holsboer, Florian
Homuth, Georg
Hosten, Norbert
Jack, Clifford R
Jang, MiHyun
Jansen, Andreas
Kimbrel, Nathan A
Kolskår, Knut
Koops, Sanne
Krug, Axel
Lim, Kelvin O
Luykx, Jurjen J
Mathalon, Daniel H
Mather, Karen A
Mattay, Venkata S
Matthews, Sarah
Mayoral Van Son, Jaqueline
McEwen, Sarah C
Melle, Ingrid
Morris, Derek W
Mueller, Bryon A
Nauck, Matthias
Nordvik, Jan E
Nöthen, Markus M
O'Leary, Daniel S
Opel, Nils
Martinot, Marie-Laure Paillère
Pike, G Bruce
Preda, Adrian
Quinlan, Erin B
Rasser, Paul E
Ratnakar, Varun
Reppermund, Simone
Steen, Vidar M
Tooney, Paul A
Torres, Fábio R
Veltman, Dick J
Voyvodic, James T
Whelan, Robert
White, Tonya
Yamamori, Hidenaga
Adams, Hieab HH
Bis, Joshua C
Debette, Stephanie
Decarli, Charles
Fornage, Myriam
Gudnason, Vilmundur
Hofer, Edith
Ikram, M Arfan
Launer, Lenore
Longstreth, WT
Lopez, Oscar L
Mazoyer, Bernard
Mosley, Thomas H
Roshchupkin, Gennady V
Satizabal, Claudia L
Schmidt, Reinhold
Seshadri, Sudha
Yang, Qiong
Alzheimer’s Disease Neuroimaging Initiative
CHARGE Consortium
EPIGEN Consortium
IMAGEN Consortium
SYS Consortium
Parkinson’s Progression Markers Initiative
Alvim, Marina KM
Ames, David
Anderson, Tim J
Andreassen, Ole A
Arias-Vasquez, Alejandro
Bastin, Mark E
Baune, Bernhard T
Beckham, Jean C
Blangero, John
Boomsma, Dorret I
Brodaty, Henry
Brunner, Han G
Buckner, Randy L
Buitelaar, Jan K
Bustillo, Juan R
Cahn, Wiepke
Cairns, Murray J
Calhoun, Vince
Carr, Vaughan J
Caseras, Xavier
Caspers, Svenja
Cavalleri, Gianpiero L
Cendes, Fernando
Corvin, Aiden
Crespo-Facorro, Benedicto
Dalrymple-Alford, John C
Dannlowski, Udo
de Geus, Eco JC
Deary, Ian J
Delanty, Norman
Depondt, Chantal
Desrivières, Sylvane
Donohoe, Gary
Espeseth, Thomas
Fernández, Guillén
Fisher, Simon E
Flor, Herta
Forstner, Andreas J
Francks, Clyde
Franke, Barbara
Glahn, David C
Gollub, Randy L
Grabe, Hans J
Gruber, Oliver
Håberg, Asta K
Hariri, Ahmad R
Hartman, Catharina A
Hashimoto, Ryota
Heinz, Andreas
Henskens, Frans A
Hillegers, Manon HJ
Hoekstra, Pieter J
Holmes, Avram J
Hong, L Elliot
Hopkins, William D
Hulshoff Pol, Hilleke E
Jernigan, Terry L
Jönsson, Erik G
Kahn, René S
Kennedy, Martin A
Kircher, Tilo TJ
Kochunov, Peter
Kwok, John BJ
Le Hellard, Stephanie
Loughland, Carmel M
Martin, Nicholas G
Martinot, Jean-Luc
McDonald, Colm
McMahon, Katie L
Meyer-Lindenberg, Andreas
Michie, Patricia T
Morey, Rajendra A
Mowry, Bryan
Nyberg, Lars
Oosterlaan, Jaap
Ophoff, Roel A
Pantelis, Christos
Paus, Tomas
Pausova, Zdenka
Penninx, Brenda WJH
Polderman, Tinca JC
Posthuma, Danielle
Rietschel, Marcella
Roffman, Joshua L
Rowland, Laura M
Sachdev, Perminder S
Sämann, Philipp G
Schall, Ulrich
Schumann, Gunter
Scott, Rodney J
Sim, Kang
Sisodiya, Sanjay M
Smoller, Jordan W
Sommer, Iris E
St Pourcain, Beate
Stein, Dan J
Toga, Arthur W
Trollor, Julian N
Van der Wee, Nic JA
van 't Ent, Dennis
Völzke, Henry
Walter, Henrik
Weber, Bernd
Weinberger, Daniel R
Wright, Margaret J
Zhou, Juan
Stein, Jason L
Thompson, Paul M
Medland, Sarah E
Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group
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Abstract
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
Type
Journal article
Subject
Alzheimer’s Disease Neuroimaging Initiative
CHARGE Consortium
EPIGEN Consortium
IMAGEN Consortium
SYS Consortium
Parkinson’s Progression Markers Initiative
Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group
Permalink
https://hdl.handle.net/10161/20340
Published Version (Please cite this version)
10.1126/science.aay6690
Publication Info
Grasby, Katrina L; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita; Hibar, Derrek P; ... Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group (2020). The genetic architecture of the human cerebral cortex. Science (New York, N.Y.), 367(6484). pp. eaay6690-eaay6690. 10.1126/science.aay6690. Retrieved from https://hdl.handle.net/10161/20340.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

Ashley-Koch

Allison Elizabeth Ashley-Koch

Professor in Medicine
One of my major research foci is in the genetic basis of psychiatric and neurological disorders. I am currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

Aysenil Belger

Adjunct Assistant Professor in Radiology
Hauser

Michael Arthur Hauser

Professor in Medicine
Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Cente
Kimbrel

Nathan Andrew Kimbrel

Associate Professor in Psychiatry and Behavioral Sciences
My primary areas of interest include the etiology, assessment, and treatment of PTSD, depression, suicide, and non-suicidal self-injury. I primarily work with veterans, firefighters, and emergency medical personnel due to their high levels of occupational exposure to traumatic stress. I also have long-standing interests in genetics, epigenetics, GxE research, personality, smoking, comorbidity, and statistical modeling procedures, such as CFA, SEM, and mixture modeling.
Morey

Rajendra A. Morey

Associate Professor of Psychiatry and Behavioral Sciences
Research in my lab is focused on brain changes associated with posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and other neuropsychiatric disorders. We apply several advanced methods for understanding brain function including functional MRI, structural MRI, diffusion tensor imaging, and genetic effects.
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