Regulation of spine structural plasticity by Arc/Arg3.1.
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Dendritic spines are actin-rich, postsynaptic protrusions that contact presynaptic terminals to form excitatory chemical synapses. These synaptic contacts are widely believed to be the sites of memory formation and information storage, and changes in spine shape are thought to underlie several forms of learning-related plasticity. Both membrane trafficking pathways and the actin cytoskeleton drive activity-dependent structural and functional changes in dendritic spines. A key molecular player in regulating these processes is the activity-regulated cytoskeleton-associated protein (Arc), a protein that has diverse roles in expression of synaptic plasticity. In this review, we highlight important findings that have shaped our understanding of Arc's functions in structural and functional plasticity, as well as Arc's contributions to memory consolidation and disease.
Nerve Tissue Proteins
Published Version (Please cite this version)10.1016/j.semcdb.2017.09.022
Publication InfoNewpher, Thomas M; Harris, Scott; Pringle, Jasmine; Hamilton, Colleen; & Soderling, Scott (2018). Regulation of spine structural plasticity by Arc/Arg3.1. Seminars in cell & developmental biology, 77. pp. 25-32. 10.1016/j.semcdb.2017.09.022. Retrieved from https://hdl.handle.net/10161/21087.
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Assistant Professor of the Practice of Psychology and Neuroscience
Dr. Newpher teaches and advises for Duke's Undergraduate Studies in Neuroscience program. He also directs the Summer Neuroscience Program of Research in the Duke Institute for Brain Sciences. Dr. Newpher earned his Ph.D. in molecular biology from Case Western Reserve University. He then came to Duke to receive postdoctoral training in the Department of Neurobiology, where his research focused on identifying key molecular mechanisms that underlie learning-related synaptic
George Barth Geller Distinguished Professor of Molecular Biology
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