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Regulation of spine structural plasticity by Arc/Arg3.1.

dc.contributor.author Newpher, Thomas M
dc.contributor.author Harris, Scott
dc.contributor.author Pringle, Jasmine
dc.contributor.author Hamilton, Colleen
dc.contributor.author Soderling, Scott
dc.date.accessioned 2020-06-26T23:03:56Z
dc.date.available 2020-06-26T23:03:56Z
dc.date.issued 2018-05
dc.identifier S1084-9521(17)30010-1
dc.identifier.issn 1084-9521
dc.identifier.issn 1096-3634
dc.identifier.uri https://hdl.handle.net/10161/21087
dc.description.abstract Dendritic spines are actin-rich, postsynaptic protrusions that contact presynaptic terminals to form excitatory chemical synapses. These synaptic contacts are widely believed to be the sites of memory formation and information storage, and changes in spine shape are thought to underlie several forms of learning-related plasticity. Both membrane trafficking pathways and the actin cytoskeleton drive activity-dependent structural and functional changes in dendritic spines. A key molecular player in regulating these processes is the activity-regulated cytoskeleton-associated protein (Arc), a protein that has diverse roles in expression of synaptic plasticity. In this review, we highlight important findings that have shaped our understanding of Arc's functions in structural and functional plasticity, as well as Arc's contributions to memory consolidation and disease.
dc.language eng
dc.publisher Elsevier BV
dc.relation.ispartof Seminars in cell & developmental biology
dc.relation.isversionof 10.1016/j.semcdb.2017.09.022
dc.subject Dendritic Spines
dc.subject Synapses
dc.subject Humans
dc.subject Actins
dc.subject Cytoskeletal Proteins
dc.subject Nerve Tissue Proteins
dc.subject Memory
dc.subject Endocytosis
dc.subject Neuronal Plasticity
dc.title Regulation of spine structural plasticity by Arc/Arg3.1.
dc.type Journal article
duke.contributor.id Newpher, Thomas M|0413788
duke.contributor.id Harris, Scott|0648825
duke.contributor.id Pringle, Jasmine|0645995
duke.contributor.id Hamilton, Colleen|0638011
duke.contributor.id Soderling, Scott|0378340
dc.date.updated 2020-06-26T23:03:54Z
pubs.begin-page 25
pubs.end-page 32
pubs.organisational-group Trinity College of Arts & Sciences
pubs.organisational-group Psychology and Neuroscience
pubs.organisational-group Duke Institute for Brain Sciences
pubs.organisational-group Duke
pubs.organisational-group University Institutes and Centers
pubs.organisational-group Institutes and Provost's Academic Units
pubs.organisational-group School of Medicine
pubs.organisational-group Duke Cancer Institute
pubs.organisational-group Cell Biology
pubs.organisational-group Neurobiology
pubs.organisational-group Institutes and Centers
pubs.organisational-group Basic Science Departments
pubs.organisational-group Student
pubs.publication-status Published
pubs.volume 77


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