Skip to main content
Duke University Libraries
DukeSpace Scholarship by Duke Authors
  • Login
  • Ask
  • Menu
  • Login
  • Ask a Librarian
  • Search & Find
  • Using the Library
  • Research Support
  • Course Support
  • Libraries
  • About
View Item 
  •   DukeSpace
  • Theses and Dissertations
  • Masters Theses
  • View Item
  •   DukeSpace
  • Theses and Dissertations
  • Masters Theses
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Localized Correlation Analysis and Genetic Association with Cardiovascular Disease

Thumbnail
View / Download
8.1 Mb
Date
2010
Author
Ou, Chern-Han
Advisor
Hauser, Elizabeth R
Repository Usage Stats
434
views
343
downloads
Abstract

Variations in gene expression are potential risk factors for atherosclerosis, which is one of the most common forms of cardiovascular disease. We performed a localized Pearson correlation test in 372 individuals from seven datasets relevant to cardiovascular disease studies. The genomes of samples were separated into 20Mb windows and correlation tests were performed locally in these windows. The localized Pearson correlation test found chr3:115Mb&ndash;135Mb was tightly connected by significantly high proportion of highly correlated pairs (<italic>P</italic> value = 0.0266 with Z-test). LSAMP, GATA2, MBD4, and other genes in the region were considered associated with cardiovascular disease because they were involved in highly correlated pairs. Furthermore, these genes were also associated with cardiovascular disease by having significantly high SNP odds ratios (<italic>P</italic> value < 0.1) between patients and controls in an independent Duke University Medical Center database. In addition, a permutation test was performed to demonstrate that chr3:115Mb&ndash;135Mb might underlie the regulation of cardiovascular disease. Finally, the localized Pearson correlation test also found some other regions that could be associated with cardiovascular disease.

Type
Master's thesis
Department
Computational Biology and Bioinformatics
Subject
Biology, Bioinformatics
Biology, Genetics
Biology, Biostatistics
Cardiovascular Disease
Correlation
Gene expression
Genetics
Genomics
Permalink
https://hdl.handle.net/10161/2501
Citation
Ou, Chern-Han (2010). Localized Correlation Analysis and Genetic Association with Cardiovascular Disease. Master's thesis, Duke University. Retrieved from https://hdl.handle.net/10161/2501.
Collections
  • Masters Theses
More Info
Show full item record
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License.

Rights for Collection: Masters Theses


Works are deposited here by their authors, and represent their research and opinions, not that of Duke University. Some materials and descriptions may include offensive content. More info

Make Your Work Available Here

How to Deposit

Browse

All of DukeSpaceCommunities & CollectionsAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit DateThis CollectionAuthorsTitlesTypesBy Issue DateDepartmentsAffiliations of Duke Author(s)SubjectsBy Submit Date

My Account

LoginRegister

Statistics

View Usage Statistics
Duke University Libraries

Contact Us

411 Chapel Drive
Durham, NC 27708
(919) 660-5870
Perkins Library Service Desk

Digital Repositories at Duke

  • Report a problem with the repositories
  • About digital repositories at Duke
  • Accessibility Policy
  • Deaccession and DMCA Takedown Policy

TwitterFacebookYouTubeFlickrInstagramBlogs

Sign Up for Our Newsletter
  • Re-use & Attribution / Privacy
  • Harmful Language Statement
  • Support the Libraries
Duke University