Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive boron dyes for tumor accumulation.
Abstract
Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics.
Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are
one class of biomaterial utilized for these purposes. The incorporation of luminescent
molecules into NPs adds optical imaging and sensing capability to these vectors. Here
we report on the synthesis of dual-emissive, pegylated NPs with "stealth"-like properties,
delivered intravenously (IV), for the study of tumor accumulation. The NPs were created
by means of stereocomplexation using a methoxy-terminated polyethylene glycol and
poly(D-lactide) (mPEG-PDLA) block copolymer combined with iodide-substituted difluoroboron
dibenzoylmethane-poly(L-lactide) (BF2dbm(I)PLLA). Boron nanoparticles (BNPs) were
fabricated in two different solvent compositions to study the effects on BNP size
distribution. The physical and photoluminescent properties of the BNPs were studied
in vitro over time to determine stability. Finally, preliminary in vivo results show
that stereocomplexed BNPs injected IV are taken up by tumors, an important prerequisite
to their use as hypoxia imaging agents in preclinical studies.
Type
Journal articleSubject
AbsorptionAnimals
Biological Transport
Boron
Coloring Agents
Lactic Acid
Mammary Neoplasms, Experimental
Mice
Molecular Imaging
Nanomedicine
Nanoparticles
Polyesters
Polyethylene Glycols
Polymers
Solvents
Spectrum Analysis
Stereoisomerism
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https://hdl.handle.net/10161/4104Published Version (Please cite this version)
10.1021/nn901873tPublication Info
Kersey, Farrell R; Zhang, Guoqing; Palmer, Gregory M; Dewhirst, Mark W; & Fraser,
Cassandra L (2010). Stereocomplexed poly(lactic acid)-poly(ethylene glycol) nanoparticles with dual-emissive
boron dyes for tumor accumulation. ACS Nano, 4(9). pp. 4989-4996. 10.1021/nn901873t. Retrieved from https://hdl.handle.net/10161/4104.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Mark Wesley Dewhirst
Gustavo S. Montana Distinguished Professor Emeritus of Radiation Oncology
Mark W. Dewhirst, DVM, PhD is the Gustavo S. Montana Professor of Radiation Oncology
and Vice Director for Basic Science in the Duke Cancer Institute. Dr. Dewhirst has
research interests in tumor hypoxia, angiogenesis, hyperthermia and drug transport.
He has spent 30 years studying causes of tumor hypoxia and the use of hyperthermia
to treat cancer. In collaboration with Professor David Needham in the Pratt School
of Engineering, he has developed a novel thermally sensitive drug carrying liposom
Farrell Ray Kersey
Lecturing Fellow of Chemistry
Gregory M. Palmer
Associate Professor of Radiation Oncology
Greg Palmer obtained his B.S. in Biomedical Engineering from Marquette University
in 2000, after which he obtained his Ph.D. in BME from the University of Wisconsin,
Madison. He is currently an Associate Professor in the Department of Radiation Oncology,
Cancer Biology Division at Duke University Medical Center. His primary research focus
has been identifying and exploiting the changes in absorption, scattering, and fluorescence
properties of tissue associated with cancer progression and therape
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