Host determinants of HIV-1 control in African Americans.
Date
2010-04-15
Authors
National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine
Immunology (CHAVI)
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Abstract
We performed a whole-genome association study of human immunodeficiency virus type
1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic
single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest
associations. We use a subset of patients to demonstrate that this SNP reflects the
effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant
association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore
confirm a member of the HLA-B*57 group of alleles as the most important common variant
that influences viral load variation in African Americans, which is consistent with
what has been observed for individuals of European ancestry, among whom the most important
common variant is HLA-B*5701.
Type
Journal articleSubject
AdolescentAdult
African Americans
DNA-Binding Proteins
Disease Progression
Genome-Wide Association Study
Genotype
HIV Infections
HIV-1
HLA-B Antigens
HLA-C Antigens
Humans
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Viral Load
Young Adult
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https://hdl.handle.net/10161/4146Published Version (Please cite this version)
10.1086/651382Publication Info
Pelak, Kimberly; Goldstein, David B; Walley, Nicole M; Fellay, Jacques; Ge, Dongliang;
Shianna, Kevin V; ... National Institute of Allergy and Infectious Diseases Center
for HIV/AIDS Vaccine Immunology (CHAVI) (2010). Host determinants of HIV-1 control in African Americans. J Infect Dis, 201(8). pp. 1141-1149. 10.1086/651382. Retrieved from https://hdl.handle.net/10161/4146.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
David Benjamin Goldstein
Adjunct Professor in the Department of Molecular Genetics and Microbiology

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