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Host determinants of HIV-1 control in African Americans.

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Date
2010-04-15
Authors
Pelak, Kimberly
Goldstein, David B
Walley, Nicole M
Fellay, Jacques
Ge, Dongliang
Shianna, Kevin V
Gumbs, Curtis
Gao, Xiaojiang
Maia, Jessica M
Cronin, Kenneth D
Hussain, Shehnaz K
Carrington, Mary
Michael, Nelson L
Weintrob, Amy C
Infectious Disease Clinical Research Program HIV Working Group
National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI)
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Abstract
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
Type
Journal article
Subject
Adolescent
Adult
African Americans
DNA-Binding Proteins
Disease Progression
Genome-Wide Association Study
Genotype
HIV Infections
HIV-1
HLA-B Antigens
HLA-C Antigens
Humans
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Viral Load
Young Adult
Permalink
https://hdl.handle.net/10161/4146
Published Version (Please cite this version)
10.1086/651382
Publication Info
Pelak, Kimberly; Goldstein, David B; Walley, Nicole M; Fellay, Jacques; Ge, Dongliang; Shianna, Kevin V; ... National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) (2010). Host determinants of HIV-1 control in African Americans. J Infect Dis, 201(8). pp. 1141-1149. 10.1086/651382. Retrieved from https://hdl.handle.net/10161/4146.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
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Scholars@Duke

David Benjamin Goldstein

Adjunct Professor in the Department of Molecular Genetics and Microbiology
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