Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors.
Type
Journal articleSubject
Adenylyl CyclasesAdrenergic beta-Agonists
Affinity Labels
Animals
Asthma
Catecholamines
Coronary Disease
Cyclic AMP
Heart Failure
Humans
Hypertension
In Vitro Techniques
Models, Biological
Propranolol
Radioligand Assay
Receptors, Adrenergic
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Receptors, Cell Surface
Thyroid Diseases
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https://hdl.handle.net/10161/5927Published Version (Please cite this version)
10.1056/NEJM198406143102406Publication Info
Lefkowitz, RJ; Caron, MG; & Stiles, GL (1984). Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical
insights derived from studies of the adrenergic receptors. N Engl J Med, 310(24). pp. 1570-1579. 10.1056/NEJM198406143102406. Retrieved from https://hdl.handle.net/10161/5927.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Marc G. Caron
James B. Duke Distinguished Professor of Cell Biology
Studies of the mechanisms of action and regulation of hormones and neurotransmitters
at the cellular and molecular levels constitute the main goals our of research activities.
G protein-coupled receptors (GPCR) mediate the actions of signaling molecules from
unicellular organisms to man. We have used adrenergic and dopamine receptors to characterize
the structure/function and regulation mechanisms of these prototypes of G protein-coupled
receptors. Another approach has been to characterize
This author no longer has a Scholars@Duke profile, so the information shown here reflects
their Duke status at the time this item was deposited.
Robert J. Lefkowitz
The Chancellor's Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his
early career as a cardiologist and his transition to biochemistry, which led to his
Nobel Prize win.
Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of
Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator
of the
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