Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors.
Type
Journal articleSubject
Adenylyl CyclasesAdrenergic beta-Agonists
Affinity Labels
Animals
Asthma
Catecholamines
Coronary Disease
Cyclic AMP
Heart Failure
Humans
Hypertension
In Vitro Techniques
Models, Biological
Propranolol
Radioligand Assay
Receptors, Adrenergic
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Receptors, Cell Surface
Thyroid Diseases
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https://hdl.handle.net/10161/5927Published Version (Please cite this version)
10.1056/NEJM198406143102406Publication Info
(1984). Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical
insights derived from studies of the adrenergic receptors. N Engl J Med, 310(24). pp. 1570-1579. 10.1056/NEJM198406143102406. Retrieved from https://hdl.handle.net/10161/5927.This is constructed from limited available data and may be imprecise. To cite this
article, please review & use the official citation provided by the journal.
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Show full item recordScholars@Duke
Robert J. Lefkowitz
James B. Duke Professor of Medicine
The focus of work in this laboratory is on the elucidation of the molecular properties
and regulatory mechanisms controlling the function of G protein-coupled receptors.
As model systems we utilize the so called adrenergic receptors for adrenaline and
related molecules. The goal is to learn the general principles of signal transduction
from the outside to the inside of the cell which are involved in systems as diverse
as sensory perception, neuro- transmitter and hormonal signaling. Stud
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
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