Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors.

Date
1984-06-14
Authors
Lefkowitz, RJ
Caron, MG
Stiles, GL
Repository Usage Stats
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410
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Type
Journal article
Subject
Adenylyl Cyclases
Adrenergic beta-Agonists
Affinity Labels
Animals
Asthma
Catecholamines
Coronary Disease
Cyclic AMP
Heart Failure
Humans
Hypertension
In Vitro Techniques
Models, Biological
Propranolol
Radioligand Assay
Receptors, Adrenergic
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Receptors, Cell Surface
Thyroid Diseases
Permalink
https://hdl.handle.net/10161/5927
Published Version (Please cite this version)
10.1056/NEJM198406143102406
Publication Info
Lefkowitz, RJ; Caron, MG; & Stiles, GL (1984). Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. N Engl J Med, 310(24). pp. 1570-1579. 10.1056/NEJM198406143102406. Retrieved from https://hdl.handle.net/10161/5927.
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Scholars@Duke

Caron

Marc G. Caron

James B. Duke Distinguished Professor of Cell Biology
Studies of the mechanisms of action and regulation of hormones and neurotransmitters at the cellular and molecular levels constitute the main goals our of research activities. G protein-coupled receptors (GPCR) mediate the actions of signaling molecules from unicellular organisms to man. We have used adrenergic and dopamine receptors to characterize the structure/function and regulation mechanisms of these prototypes of G protein-coupled receptors. Another approach has been to characterize
Lefkowitz

Robert J. Lefkowitz

James B. Duke Distinguished Professor of Medicine
Dr. Lefkowitz’s memoir, A Funny Thing Happened on the Way to Stockholm, recounts his early career as a cardiologist and his transition to biochemistry, which led to his Nobel Prize win. Robert J. Lefkowitz, M.D. is James B. Duke Professor of Medicine and Professor of Biochemistry and Chemistry at the Duke University Medical Center. He has been an Investigator of the
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