Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors.
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In Vitro Techniques
Receptors, Adrenergic, alpha
Receptors, Adrenergic, beta
Receptors, Cell Surface
Published Version (Please cite this version)10.1056/NEJM198406143102406
Publication InfoCaron, MG; Lefkowitz, Robert J; & Stiles, GL (1984). Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors. N Engl J Med, 310(24). pp. 1570-1579. 10.1056/NEJM198406143102406. Retrieved from http://hdl.handle.net/10161/5927.
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James B. Duke Professor of Medicine
The focus of work in this laboratory is on the elucidation of the molecular properties and regulatory mechanisms controlling the function of G protein-coupled receptors. As model systems we utilize the so called adrenergic receptors for adrenaline and related molecules. The goal is to learn the general principles of signal transduction from the outside to the inside of the cell which are involved in systems as diverse as sensory perception, neuro- transmitter and hormonal signaling. Stud
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