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Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila.

dc.contributor.author Gou, B
dc.contributor.author Liu, Y
dc.contributor.author Guntur, AR
dc.contributor.author Stern, U
dc.contributor.author Yang, CH
dc.coverage.spatial United States
dc.date.accessioned 2014-10-17T15:33:46Z
dc.date.issued 2014-10-23
dc.identifier http://www.ncbi.nlm.nih.gov/pubmed/25373900
dc.identifier S2211-1247(14)00816-X
dc.identifier.uri https://hdl.handle.net/10161/9191
dc.description.abstract Selecting a suitable site to deposit their eggs is an important reproductive need of Drosophila females. Although their choosiness toward egg-laying sites is well documented, the specific neural mechanism that activates females' search for attractive egg-laying sites is not known. Here, we show that distention and contraction of females' internal reproductive tract triggered by egg delivery through the tract plays a critical role in activating such search. We found that females start to exhibit acetic acid (AA) attraction prior to depositing each egg but no attraction when they are not laying eggs. Artificially distending the reproductive tract triggers AA attraction in non-egg-laying females, whereas silencing the mechanosensitive neurons we identified that can sense the contractile status of the tract eliminates such attraction. Our work uncovers the circuit basis of an important reproductive need of Drosophila females and provides a simple model for dissecting the neural mechanism that underlies a reproductive need-induced behavioral modification.
dc.language eng
dc.relation.ispartof Cell Rep
dc.relation.isversionof 10.1016/j.celrep.2014.09.033
dc.subject Acetic Acid
dc.subject Animals
dc.subject Drosophila
dc.subject Drosophila Proteins
dc.subject Female
dc.subject Mechanoreceptors
dc.subject Oviducts
dc.subject Oviposition
dc.subject Sodium Channels
dc.title Mechanosensitive neurons on the internal reproductive tract contribute to egg-laying-induced acetic acid attraction in Drosophila.
dc.type Journal article
pubs.author-url http://www.ncbi.nlm.nih.gov/pubmed/25373900
pubs.begin-page 522
pubs.end-page 530
pubs.issue 2
pubs.organisational-group Basic Science Departments
pubs.organisational-group Duke
pubs.organisational-group Neurobiology
pubs.organisational-group School of Medicine
pubs.publication-status Published
pubs.volume 9
dc.identifier.eissn 2211-1247


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