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Access status: Open Access ,
Quality cancer care for older adults from culturally and linguistically diverse backgrounds: Perspectives from the Cancer and Aging Research Group Junior Board
(Journal of Geriatric Oncology) Singhal, Surbhi; Abdallah, Maya; Phillips, Tanyanika; Arrato, Nicole A; Roy, Mukul; Werts-Pelter, Samantha; Ramos, Katherine; Han, Chad Yixian
Access status: Open Access ,
Learning about culturally humble care of sexual and gender minority patients.
(Teaching and learning in nursing : official journal of the National Organization for Assciate Degree Nursing, 2019-07) Bell, Lacrecia M; Brennan-Cook, Jill; Sisson, Julia; Steigerwald, Molly; Cook, Christian; Cicero, Ethan C; Cary, Michael P
Each day, nurses care for patients from diverse cultures and backgrounds, including those who self-identify as lesbian, gay, bisexual, transgender, or queer. To facilitate productive health partnerships, nurses need to be aware of a patient's sexual orientation, gender identity, and expression. Prelicensure nursing students employed cultural humility with the use of a video and a guided discussion. The purpose of this article is to describe teaching strategies that can be used by other nurse educators.
Access status: Open Access ,
B-299 Selegiline Metabolism Mimicking Illicit Drug Use: A Case of Amphetamine-Positive Meconium
(Clinical Chemistry, 2025-10-02) Metushi, Imir; Ayodele, Victoria; Wang, Claudia
Abstract Background Immunoassays are commonly used in clinical settings for rapid drug screening, yet they are prone to cross-reactivity and interference from medications and substances, leading to false-positive results. Because of this, follow up confirmatory testing by either liquid chromatography-mass spectrometry (LC-MS) or gas chromatography-mass spectrometry (GC-MS) is highly recommended. An infant*s meconium tested positive for amphetamine and methamphetamine by mass spectrometry but mother denied substance abuse and claimed to be taking selegiline for anxiety. The clinical implications of differentiating between amphetamine misuse versus a prescribed medication are significant, particularly during and after a pregnancy where a positive result may trigger a newborn risk assessment which could lead to a report to child protective services. This case highlights the need to understand potential cross-reactivity of medications with drug screening and confirmation testing methods. Methods We analyzed the case of an infant, exploring the biochemical pathway of selegiline and its potential to produce metabolites that can lead to a positive amphetamine result by either immunoassays and/or mass spectrometry. Mass spectrometry testing on meconium of the infant was performed at a send out reference laboratory. A literature review was conducted to identify other medications and substances that commonly cause cross-reactivity in immunoassays. Some general findings are synthesized into the table. Results Results of a drug screen on the meconium came back positive for amphetamine and methamphetamine when analyzed by mass spectrometry, this sparked concern with the medical team. Selegiline is metabolized into l-methamphetamine and l-amphetamine. The mass spectrometry method did not distinguish between (d) and (l) amphetamine/methamphetamine, it was concluded that the observer results could be from selegiline metabolism. A review of the literature revealed numerous medications and substances that interfere with immunoassay drug screens as shown in Table 1. Conclusion This case underscores the critical importance of confirmatory testing and clinical correlation in drug screening/confirmation, particularly in sensitive cases such as pregnancy. Understanding drugs of abuse screen and confirmation procedures, and potential agents that can cause positive results is crucial to prevent misdiagnosis and unnecessary interventions, safeguarding patient care.
Access status: Open Access ,
Mechanical states of a motor protein in the spindle
(Current Biology, 2026-01) Do, Kevin K; Greear, Ian; Paul, Umika S; Billington, Neil; Meng, Zimiao; Wang, Matthew Y; Liu, Rong; Hoffman, Brenton D; Endow, Sharyn A
Access status: Open Access ,
The fungal STRIPAK complex: Cellular conductor orchestrating growth and pathogenicity.
(PLoS pathogens, 2025-09) Peterson, Patricia P; Heitman, Joseph