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Access status: Open Access ,
Reconfigurable quantum computer juggles 98 qubits.
(Nature, 2026-07) Noel, Crystal
A quantum computer based on trapped ions can connect any two quantum bits, reaching performance levels that conventional computers cannot match.
Access status: Open Access ,
How to Build a Community Advisory Board (CAB): Tips and Lessons Learned from the Hospital-to-Home (H2H) Transitional Care Study for Children and Youth with Special Health Care Needs (CYSHCN) Community Advisory Board
(2026-07-15) Kmitch, Laura; Ediae, Esosa; Ming, David; deJong, Neal; McDermott, Nathan; Sanwo, Daniel; Robinson, Dalya
Access status: Open Access ,
Hospital and operator procedural volumes and one-year outcomes for TAVR in the United States: A STS/ACC TVT Registry Analysis
Vemulapalli, Sreekanth
Background: Prior analyses have demonstrated an inverse association between transcatheter aortic valve replacement (TAVR) procedural volume and short-term outcomes. However, less is known regarding the relationship between procedural volume and 1-year outcomes in the contemporary TAVR era. Objectives: To evaluate the association between annual hospital and operator TAVR procedural volumes and 1-year clinical outcomes in a contemporary national cohort. Methods: Clinical records from the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapies (TVT) Registry for patients undergoing commercial TAVR between January 2020 and December 2022 were linked to Centers for Medicare & Medicaid Services administrative claims. Annualized hospital and operator TAVR volumes were modeled continuously and categorized into tertiles. Primary outcomes included 1-year all-cause mortality, stroke, the composite of mortality or stroke, and all-cause readmissions. Hierarchical risk-adjusted models accounting for patient clustering within sites were used to evaluate associations between procedural volume and outcomes. Results: Among 215,335 patients undergoing TAVR at 788 hospitals by 3,444 operators between 2020 and 2022, median annual hospital and operator volumes were 74 (IQR: 43-115) and 16 (IQR: 10-32), respectively. Volume was then categorized into tertiles (low, medium and high). Compared with high-volume hospitals (≥102/year), low-volume hospitals (≤52/year) had higher adjusted rates of 1-year all-cause mortality (Odds Ratio (OR): 1.10 [95% CI: 1.05-1.16]), stroke (OR: 1.10 [95% CI: 1.01-1.19]), mortality or stroke (OR: 1.10 [95% CI: 1.05-1.15]), and all-cause readmissions (OR: 1.05 [95% CI: 1.00-1.09]). Compared with high-volume operators (≥25/year), low-volume operators (≤11/year) had higher adjusted rates of stroke (OR: 1.16 [95% CI: 1.05-1.28]) and mortality or stroke (OR: 1.09 [95% CI: 1.03-1.15]) but not other endpoints. Conclusions: In a large, contemporary national TAVR registry, lower annual hospital (≤ 52/year) and operator (≤ 11/year) procedural volumes were independently associated with worse 1-year clinical outcomes. These findings suggest that procedural experience continues to influence outcomes despite maturation of contemporary TAVR practice.
Access status: Open Access ,
Unexpected Breakdown: Influenza A-Associated Rhabdomyolysis in the 2024-2025 Season.
(Mayo Clinic proceedings, 2026-05) Chan, Justin M; Roomiany, Pahresah L; Naeem, Halima A; Hruby, Carter W
Access status: Open Access ,
Tropicalization of mid-western Atlantic coastal bays by pinfish Lagodon rhomboides: a combined ecological and oceanographic perspective
(Marine Ecology Progress Series, 2024-01-01) Lefcheck, JS; Orth, RJ; Fodrie, FJ; Gong, D; Faulkner, M; Laumann, KM; Patrick, CJ
As climate change continues to shift the distributions of species worldwide, understanding where, why, and how organisms move beyond their historical ranges is of critical importance. Here, we report on the expansion of pinfish Lagodon rhomboides poleward along the mid-western Atlantic in response to rising temperatures. Pinfish are a key interactor in nearshore subtidal habitats like seagrasses in the southwestern Atlantic and Gulf of Mexico, but they have been historically sparse north of the ecotone at Cape Hatteras, North Carolina, USA. Using multidecadal trawl surveys, we show that while pinfish have been present both below (North Carolina) and above (Virginia and Maryland) this ecotone for many years, they have increasingly intruded into restored eelgrass (Zostera marina) meadows in the coastal bays of Virginia over the past decade. In 2022, for instance, pinfish abundances in Virginia equaled those observed historically in North Carolina. To understand the factors promoting these changes in abundance, we used a passive drifter model to show that these increases are not necessarily tied to changes in offshore currents. Instead, linear models revealed that the local abundance of pinfish in Virginia correlates most with inshore summertime water temperatures. Thus, favorable environmental conditions of the recipient bays appear to encourage greater recruitment and therefore greater abundance of pinfish. Given their outsized ecological role in subtropical ecosystems, and that the climate will continue to warm, our findings suggest that pinfish may soon come to dominate the structure and functioning of temperate seagrass meadows in Virginia and beyond.