Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval.
Date
2005
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Citation Stats
Abstract
Functional MRI was used to investigate the role of medial temporal lobe and inferior frontal lobe regions in autobiographical recall. Prior to scanning, participants generated cue words for 50 autobiographical memories and rated their phenomenological properties using our autobiographical memory questionnaire (AMQ). During scanning, the cue words were presented and participants pressed a button when they retrieved the associated memory. The autobiographical retrieval task was interleaved in an event-related design with a semantic retrieval task (category generation). Region-of-interest analyses showed greater activation of the amygdala, hippocampus, and right inferior frontal gyrus during autobiographical retrieval relative to semantic retrieval. In addition, the left inferior frontal gyrus showed a more prolonged duration of activation in the semantic retrieval condition. A targeted correlational analysis revealed pronounced functional connectivity among the amygdala, hippocampus, and right inferior frontal gyrus during autobiographical retrieval but not during semantic retrieval. These results support theories of autobiographical memory that hypothesize co-activation of frontotemporal areas during recollection of episodes from the personal past.
Type
Department
Description
Provenance
Citation
Permalink
Published Version (Please cite this version)
Publication Info
Greenberg, Daniel L, Heather J Rice, Julie J Cooper, Roberto Cabeza, David C Rubin and Kevin S Labar (2005). Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval. Neuropsychologia, 43(5). pp. 659–674. 10.1016/j.neuropsychologia.2004.09.002 Retrieved from https://hdl.handle.net/10161/10107.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
Scholars@Duke
David C. Rubin
For .pdfs of all publications click here
My main research interest has been in long-term memory, especially for complex (or "real-world") stimuli. This work includes the study of autobiographical memory and oral traditions, as well as prose. I have also studied memory as it is more commonly done in experimental psychology laboratories using lists. In addition to this purely behavioral research, which I plan to continue, I work on memory in clinical populations with the aid of a National Institute of Mental Health grant to study PTSD and on the underlying neural basis of memory the aid of a National Institute of Aging grant to study autobiographical memory using fMRI.
Kevin S. LaBar
My research focuses on understanding how emotional events modulate cognitive processes in the human brain. We aim to identify brain regions that encode the emotional properties of sensory stimuli, and to show how these regions interact with neural systems supporting social cognition, executive control, and learning and memory. To achieve this goal, we use a variety of cognitive neuroscience techniques in human subject populations. These include psychophysiological monitoring, functional magnetic resonance imaging (fMRI), machine learning, and behavioral studies in healthy adults as well as psychiatric patients. This integrative approach capitalizes on recent advances in the field and may lead to new insights into cognitive-emotional interactions in the brain.
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.