Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope<sup>Ⓡ</sup>-Global Registry for Emerging Fungal Infections.

dc.contributor.author

Salmanton-García, Jon

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Koehler, Philipp

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Kindo, Anupma

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Falces-Romero, Iker

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García-Rodríguez, Julio

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Ráčil, Zdeněk

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Chen, Sharon C-A

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Klimko, Nikolai

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Desoubeaux, Guillaume

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Thompson, George R

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Benítez-Peñuela, Miguel-Ángel

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Rodríguez, José-Yesid

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Sheppard, Donald C

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Hoenigl, Martin

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Le Govic, Yohann

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Badali, Hamid

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Baddley, John W

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Chander, Jagdish

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Ingram, Paul R

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Pakstis, Diana L

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Mellinghoff, Sibylle C

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Atıcı, Serkan

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Cesaro, Simone

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Chakrabarti, Arunaloke

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Dupont, Damien

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González, Gloria M

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Hatvani, Lóránt

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Herbrecht, Raoul

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Klyasova, Galina

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Lass-Flörl, Cornelia

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Mareș, Mihai

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Mullane, Kathleen

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Vinh, Donald C

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Wisplinghoff, Hilmar

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Lackner, Michaela

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Cornely, Oliver A

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Seidel, Danila

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ECMM/ISHAM working group

dc.date.accessioned

2023-08-01T18:05:39Z

dc.date.available

2023-08-01T18:05:39Z

dc.date.issued

2020-11

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2023-08-01T18:05:38Z

dc.description.abstract

Objectives

Emerging invasive fungal infections (IFI) have become a notable challenge. Apart from the more frequently described fusariosis, lomentosporiosis, mucormycosis, scedosporiosis, and certain dematiaceae or yeasts, little is known about extremely rare IFI.

Methods

Extremely rare IFI collected in the FungiScope registry were grouped as Dematiaceae, Hypocreales, Saccharomycetales, Eurotiales, Dermatomycetes, Agaricales, and Mucorales.

Results

Between 2003 and June 2019, 186 extremely rare IFI were documented in FungiScope. Dematiaceae (35.5%), Hypocreales (23.1%), Mucorales (11.8%), and Saccharomycetales (11.3%) caused most IFI. Most patients had an underlying malignancy (38.7%) with acute leukemia accounting for 50% of cancers. Dissemination was observed in 26.9% of the patients. Complete or partial clinical response rate was 68.3%, being highest in Eurotiales (82.4%) and in Agaricales (80.0%). Overall mortality rate was 29.3%, ranging from 11.8% in Eurotiales to 50.0% in Mucorales.

Conclusions

Physicians are confronted with a complex variety of fungal pathogens, for which treatment recommendations are lacking and successful outcome might be incidental. Through an international consortium of physicians and scientists, these cases of extremely rare IFI can be collected to further investigate their epidemiology and eventually identify effective treatment regimens.
dc.identifier

S0163-4453(20)30549-1

dc.identifier.issn

0163-4453

dc.identifier.issn

1532-2742

dc.identifier.uri

https://hdl.handle.net/10161/28639

dc.language

eng

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Elsevier BV

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The Journal of infection

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10.1016/j.jinf.2020.08.015

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ECMM/ISHAM working group

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Humans

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Mycoses

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Antifungal Agents

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Registries

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Invasive Fungal Infections

dc.title

Needles in a haystack: Extremely rare invasive fungal infections reported in FungiScope-Global Registry for Emerging Fungal Infections.

dc.type

Journal article

pubs.begin-page

802

pubs.end-page

815

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5

pubs.organisational-group

Duke

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School of Medicine

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Clinical Science Departments

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Medicine

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Pathology

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Medicine, Infectious Diseases

pubs.publication-status

Published

pubs.volume

81

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