Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System.

Loading...
Thumbnail Image

Date

2021-01

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

55
views
34
downloads

Citation Stats

Attention Stats

Abstract

Cellular structures provide the physical foundation for the functionality of the nervous system, and their developmental trajectory can be influenced by the characteristics of the external environment that an organism interacts with. Historical and recent works have determined that sensory experiences, particularly during developmental critical periods, are crucial for information processing in the brain, which in turn profoundly influence neuronal and non-neuronal cortical structures that subsequently impact the animals' behavioral and cognitive outputs. In this review, we focus on how altering sensory experience influences normal/healthy development of the central nervous system, particularly focusing on the cerebral cortex using the rodent whisker-to-barrel system as an illustrative model. A better understanding of structural plasticity, encompassing multiple aspects such as neuronal, glial, and extra-cellular domains, provides a more integrative view allowing for a deeper appreciation of how all aspects of the brain work together as a whole.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.3389/fncel.2021.770453

Publication Info

Chen, Chia-Chien, and Joshua C Brumberg (2021). Sensory Experience as a Regulator of Structural Plasticity in the Developing Whisker-to-Barrel System. Frontiers in cellular neuroscience, 15. p. 770453. 10.3389/fncel.2021.770453 Retrieved from https://hdl.handle.net/10161/26622.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Scholars@Duke

Chia-Chien Chen

Assistant Professor of Neuroscience at Duke Kunshan University

Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.