Association between donor gamete use and supernumerary embryo disposition decisions.
Date
2023-02
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Abstract
Purpose
The aim of this study is to determine if donor gamete use is associated with patients' decisions regarding disposition of supernumerary embryos.Methods
Patients who intended to undergo an IVF cycle at a single academic center signed an embryo disposition consent form to indicate their disposition preferences for any supernumerary embryos. A retrospective chart review was performed to obtain the embryo disposition declarations and demographic information. The primary outcome was the distribution of embryo disposition choices between patients who used donor gametes compared to patients who did not use donor gametes. Fisher's exact test was used to compare groups. Logistic regression models were created to determine the association between donor gamete use and disposition decision after adjusting for patient age, body mass index, and nulliparity.Results
Five hundred six patients were included. Ninety-one (18.0%) patients used donor gametes [46 (9.0%) donor oocytes, 52 (10.3%) donor sperm]. Patients using donor gametes differed from those not using donor gametes when making decisions concerning death of the patient (P < 0.01), simultaneous death (P = 0.04), separation (P < 0.01), discontinuation of ART (P = 0.01), and time-limited storage (P < 0.01). Most patients, regardless of donor or autologous gamete use, awarded embryos to themselves or their partner if given the option. For patients who did not choose this option, excess embryos were generally awarded to research or discarded rather than donating to another couple. Patients using donor gametes were more likely to award embryos to research over discarding.Conclusion
Patients using donor gametes made different choices regarding supernumerary embryo disposition compared to patients not using donor gametes.Type
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Tsai, Shelun, Jenna S Hynes, Nicole Zanolli, Douglas Raburn and Anne Z Steiner (2023). Association between donor gamete use and supernumerary embryo disposition decisions. Journal of assisted reproduction and genetics, 40(2). pp. 371–379. 10.1007/s10815-022-02690-y Retrieved from https://hdl.handle.net/10161/30725.
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Douglas Joe Raburn
Dr. Raburn is the Director of the Assisted Reproductive Technology Laboratories at the Duke Fertility Center. As part of the multidisciplinary team within the Reproductive Endocrinology and Infertility division, he specializes in optimizing outcomes for patients who require assisted reproduction for current and future family building. His research focuses on gamete, embryo and reproductive tissue biology.
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