Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N

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2010

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Abstract

Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control.

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Other article

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amino-acids, identification, cepacia, complex, strain, chemistry, organic

Citation

Tawfik,Kamilia A.;Jeffs,Peter;Bray,Brian;Dubay,George;Falkinham,Joseph O.,,III;Mesbah,Mostafa;Youssef,Diaa;Khalifa,Sherief;Schmidt,Eric W.. 2010. Burkholdines 1097 and 1229, Potent Antifungal Peptides from Burkholderia ambifaria 2.2N. Organic letters 12(4): 664-666.

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https://hdl.handle.net/10161/4111

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10.1021/ol9029269

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