Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?

dc.contributor.author

Erickson, Harold P

dc.coverage.spatial

United States

dc.date.accessioned

2014-12-01T19:59:00Z

dc.date.issued

2013-10-01

dc.description.abstract

FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercise, and to circulate to fat tissue where it induced a transition to brown fat. Since brown fat results in dissipation of energy, this pathway is of considerable interest for metabolism and obesity. Here I review the original discoveries of FNDC5 and the more recent discovery of irisin. I note in particular three problems in the characterization of irisin: the antibodies used to detect irisin in plasma lack validity; the recombinant protein used to demonstrate activity in cell culture was severely truncated; and the degree of shedding of soluble irisin from the cell surface has not been quantitated. The original discovery proposing that FNDC5 may be a transmembrane receptor may deserve a new look.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/24052909

dc.identifier

2013ADIPOCYTE130R

dc.identifier.issn

2162-3945

dc.identifier.uri

https://hdl.handle.net/10161/9280

dc.language

eng

dc.publisher

Informa UK Limited

dc.relation.ispartof

Adipocyte

dc.relation.isversionof

10.4161/adip.26082

dc.subject

FNDC5

dc.subject

brown adipocyte

dc.subject

exercise

dc.subject

fibronectin

dc.subject

irisin

dc.title

Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?

dc.type

Journal article

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/24052909

pubs.begin-page

289

pubs.end-page

293

pubs.issue

4

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Biochemistry

pubs.organisational-group

Cell Biology

pubs.organisational-group

Duke

pubs.organisational-group

Duke Cancer Institute

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

School of Medicine

pubs.publication-status

Published

pubs.volume

2

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