Structural and Functional Studies of Nucleoside Transporters
Date
2017
Authors
Advisors
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Abstract
Nucleoside transport is required for the salvage pathway of DNA and RNA, provides a transport route for nucleoside-like drugs and regulates adenosine signaling. The eukaryotic cell possesses two evolutionarily unrelated protein families of nucleoside transporters, the concentrative nucleoside transporters and the equilibrative nucleoside transporters. We aimed to elucidate their transport mechanisms using X-ray crystallography and biochemical assays. We solved multiple crystal structures of CNT along its transport cycle at 3.45-4.2 Å, which provide novel insights into the elevator-type transport mechanism of secondary active transporters.
Type
Department
Description
Provenance
Citation
Permalink
Citation
Hirschi, Marsha Marianne (2017). Structural and Functional Studies of Nucleoside Transporters. Dissertation, Duke University. Retrieved from https://hdl.handle.net/10161/14557.
Collections
Except where otherwise noted, student scholarship that was shared on DukeSpace after 2009 is made available to the public under a Creative Commons Attribution / Non-commercial / No derivatives (CC-BY-NC-ND) license. All rights in student work shared on DukeSpace before 2009 remain with the author and/or their designee, whose permission may be required for reuse.