The role of B cells in solid organ transplantation.

dc.contributor.author

Kwun, Jean

dc.contributor.author

Bulut, Pinar

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Kim, Eugenia

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Dar, Wasim

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Oh, Byoungchol

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Ruhil, Ravi

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Iwakoshi, Neal

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Knechtle, Stuart J

dc.coverage.spatial

England

dc.date.accessioned

2015-05-16T11:49:19Z

dc.date.issued

2012-04

dc.description.abstract

The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning of maintenance agents or due to homeostatic repopulation after immune cell depletion, the threshold of B cell activation may be lowered. In human transplant recipients the result may be donor-specific antibody, C4d+ injury, and chronic rejection. This scenario has precise parallels in a rhesus monkey renal allograft model in which T cells are depleted with CD3 immunotoxin, or in a CD52-T cell transgenic mouse model using alemtuzumab to deplete T cells. Such animal models may be useful for the testing of therapeutic strategies to prevent DSA. We agree with others who suggest that weaning of immunosuppression may place transplant recipients at risk of chronic antibody-mediated rejection, and that strategies to prevent this scenario are needed if we are to improve long-term graft and patient outcomes in transplantation. We believe that animal models will play a crucial role in defining the pathophysiology of antibody-mediated rejection and in developing effective therapies to prevent graft injury. Two such animal models are described herein.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/22137187

dc.identifier

S1044-5323(11)00098-4

dc.identifier.eissn

1096-3618

dc.identifier.uri

https://hdl.handle.net/10161/10059

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Semin Immunol

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10.1016/j.smim.2011.08.022

dc.subject

Animals

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B-Lymphocytes

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Disease Models, Animal

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Graft Rejection

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Humans

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Isoantibodies

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Macaca mulatta

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Mice

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Organ Transplantation

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Rats

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Transplantation Immunology

dc.title

The role of B cells in solid organ transplantation.

dc.type

Journal article

duke.contributor.orcid

Kwun, Jean|0000-0002-8563-5472

duke.contributor.orcid

Knechtle, Stuart J|0000-0002-1625-385X

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/22137187

pubs.begin-page

96

pubs.end-page

108

pubs.issue

2

pubs.organisational-group

Clinical Science Departments

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Duke

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Duke Clinical Research Institute

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Institutes and Centers

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School of Medicine

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Surgery

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Surgery, Abdominal Transplant Surgery

pubs.publication-status

Published

pubs.volume

24

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