Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.
dc.contributor.author | Keku, Temitope O | |
dc.contributor.author | Vidal, Adriana | |
dc.contributor.author | Oliver, Shannon | |
dc.contributor.author | Hoyo, Catherine | |
dc.contributor.author | Hall, Ingrid J | |
dc.contributor.author | Omofoye, Oluwaseun | |
dc.contributor.author | McDoom, Maya | |
dc.contributor.author | Worley, Kendra | |
dc.contributor.author | Galanko, Joseph | |
dc.contributor.author | Sandler, Robert S | |
dc.contributor.author | Millikan, Robert | |
dc.coverage.spatial | Netherlands | |
dc.date.accessioned | 2013-01-16T18:37:18Z | |
dc.date.issued | 2012-07 | |
dc.description.abstract | PURPOSE: Evaluating genetic susceptibility may clarify effects of known environmental factors and also identify individuals at high risk. We evaluated the association of four insulin-related pathway gene polymorphisms in insulin-like growth factor-1 (IGF-I) (CA)( n ) repeat, insulin-like growth factor-2 (IGF-II) (rs680), insulin-like growth factor-binding protein-3 (IGFBP-3) (rs2854744), and adiponectin (APM1 rs1501299) with colon cancer risk, as well as relationships with circulating IGF-I, IGF-II, IGFBP-3, and C-peptide in a population-based study. METHODS: Participants were African Americans (231 cases and 306 controls) and Whites (297 cases, 530 controls). Consenting subjects provided blood specimens and lifestyle/diet information. Genotyping for all genes except IGF-I was performed by the 5'-exonuclease (Taqman) assay. The IGF-I (CA)(n) repeat was assayed by PCR and fragment analysis. Circulating proteins were measured by enzyme immunoassays. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated by logistic regression. RESULTS: The IGF-I (CA)( 19 ) repeat was higher in White controls (50 %) than African American controls (31 %). Whites homozygous for the IGF-I (CA)(19) repeat had a nearly twofold increase in risk of colon cancer (OR = 1.77; 95 % CI = 1.15-2.73), but not African Americans (OR = 0.73, 95 % CI 0.50-1.51). We observed an inverse association between the IGF-II Apa1 A-variant and colon cancer risk (OR = 0.49, 95 % CI 0.28-0.88) in Whites only. Carrying the IGFBP-3 variant alleles was associated with lower IGFBP-3 protein levels, a difference most pronounced in Whites (p-trend <0.05). CONCLUSIONS: These results support an association between insulin pathway-related genes and elevated colon cancer risk in Whites but not in African Americans. | |
dc.identifier | ||
dc.identifier.eissn | 1573-7225 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | Cancer Causes Control | |
dc.relation.isversionof | 10.1007/s10552-012-9981-2 | |
dc.relation.journal | Cancer Causes and Control | |
dc.subject | Adiponectin | |
dc.subject | African Americans | |
dc.subject | Aged | |
dc.subject | C-Peptide | |
dc.subject | Colonic Neoplasms | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Female | |
dc.subject | Gene Frequency | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Genotype | |
dc.subject | Genotyping Techniques | |
dc.subject | Humans | |
dc.subject | Insulin-Like Growth Factor Binding Protein 3 | |
dc.subject | Insulin-Like Growth Factor I | |
dc.subject | Insulin-Like Growth Factor II | |
dc.subject | Logistic Models | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Polymorphism, Genetic | |
dc.subject | Risk Factors | |
dc.title | Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. | |
dc.type | Journal article | |
duke.description.issue | 7 | |
duke.description.volume | 23 | |
pubs.author-url | ||
pubs.begin-page | 1127 | |
pubs.end-page | 1138 | |
pubs.issue | 7 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Faculty | |
pubs.publication-status | Published | |
pubs.volume | 23 |
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